Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1874129..1874668 Replicon chromosome
Accession NZ_CP017542
Organism Mannheimia haemolytica strain 1405

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG593_RS09765 Protein ID WP_006247804.1
Coordinates 1874399..1874668 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG593_RS09760 Protein ID WP_006247803.1
Coordinates 1874129..1874395 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG593_RS09705 1869529..1870164 - 636 Protein_1883 transposase -
BG593_RS09715 1870265..1870975 - 711 Protein_1884 tyrosine-type recombinase/integrase -
BG593_RS09720 1870879..1871202 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG593_RS09725 1871283..1871450 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG593_RS09730 1871458..1871832 - 375 WP_006247798.1 hypothetical protein -
BG593_RS09735 1871982..1872209 + 228 Protein_1888 phage terminase large subunit family protein -
BG593_RS09740 1872234..1872629 + 396 WP_006247799.1 phage tail protein -
BG593_RS09745 1872661..1873302 + 642 WP_006247800.1 hypothetical protein -
BG593_RS09750 1873385..1873786 + 402 WP_006247801.1 hypothetical protein -
BG593_RS09755 1873831..1874061 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG593_RS09760 1874129..1874395 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG593_RS09765 1874399..1874668 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG593_RS09770 1874743..1875006 + 264 WP_006247805.1 hypothetical protein -
BG593_RS09775 1875066..1875776 + 711 WP_006253312.1 tape measure protein -
BG593_RS09780 1875754..1876044 + 291 Protein_1897 C40 family peptidase -
BG593_RS09785 1876034..1876753 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG593_RS09790 1876975..1877601 + 627 WP_006247807.1 tail assembly protein -
BG593_RS09795 1877650..1878261 + 612 WP_006253310.1 hypothetical protein -
BG593_RS09800 1878372..1879058 + 687 WP_006247808.1 hypothetical protein -
BG593_RS14165 1879068..1879226 + 159 WP_006247809.1 hypothetical protein -
BG593_RS09805 1879235..1879534 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1861516..1885722 24206
- flank IS/Tn - - 1869472..1870164 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67337 WP_006247804.1 NZ_CP017542:1874399-1874668 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67337 NZ_CP017542:1874399-1874668 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67337 WP_006247803.1 NZ_CP017542:1874129-1874395 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67337 NZ_CP017542:1874129-1874395 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References