Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1322457..1323105 Replicon chromosome
Accession NZ_CP017542
Organism Mannheimia haemolytica strain 1405

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG593_RS06870 Protein ID WP_006251221.1
Coordinates 1322929..1323105 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG593_RS06865 Protein ID WP_006251222.1
Coordinates 1322457..1322873 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG593_RS06825 1318732..1319166 + 435 WP_006251230.1 hypothetical protein -
BG593_RS06830 1319181..1320170 + 990 WP_006251229.1 encapsulin -
BG593_RS14110 1320182..1320460 + 279 WP_021279981.1 hypothetical protein -
BG593_RS06840 1320463..1320840 + 378 WP_006251227.1 hypothetical protein -
BG593_RS06845 1320840..1321184 + 345 WP_006251226.1 hypothetical protein -
BG593_RS06850 1321186..1321554 + 369 WP_006251225.1 hypothetical protein -
BG593_RS06855 1321551..1321931 + 381 WP_006251224.1 hypothetical protein -
BG593_RS06860 1321935..1322417 + 483 WP_006251223.1 phage tail protein -
BG593_RS06865 1322457..1322873 - 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG593_RS06870 1322929..1323105 - 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG593_RS06875 1323201..1323872 + 672 WP_006251220.1 hypothetical protein -
BG593_RS06880 1323887..1324120 - 234 WP_020824316.1 hypothetical protein -
BG593_RS06885 1324289..1324747 + 459 WP_006251218.1 hypothetical protein -
BG593_RS06895 1325292..1327787 + 2496 WP_006251216.1 phage tail length tape measure family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1263672..1346890 83218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67335 WP_006251221.1 NZ_CP017542:c1323105-1322929 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67335 NZ_CP017542:c1323105-1322929 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67335 WP_006251222.1 NZ_CP017542:c1322873-1322457 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67335 NZ_CP017542:c1322873-1322457 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References