Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1883853..1884392 Replicon chromosome
Accession NZ_CP017541
Organism Mannheimia haemolytica strain 1450

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG588_RS09845 Protein ID WP_006247804.1
Coordinates 1884123..1884392 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG588_RS09840 Protein ID WP_006247803.1
Coordinates 1883853..1884119 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG588_RS09785 1879253..1879888 - 636 Protein_1891 transposase -
BG588_RS09795 1879989..1880699 - 711 Protein_1892 tyrosine-type recombinase/integrase -
BG588_RS09800 1880603..1880926 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG588_RS09805 1881007..1881174 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG588_RS09810 1881182..1881556 - 375 WP_006247798.1 hypothetical protein -
BG588_RS09815 1881706..1881933 + 228 Protein_1896 phage terminase large subunit family protein -
BG588_RS09820 1881958..1882353 + 396 WP_006247799.1 phage tail protein -
BG588_RS09825 1882385..1883026 + 642 WP_006247800.1 hypothetical protein -
BG588_RS09830 1883109..1883510 + 402 WP_006247801.1 hypothetical protein -
BG588_RS09835 1883555..1883785 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG588_RS09840 1883853..1884119 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG588_RS09845 1884123..1884392 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG588_RS09850 1884467..1884730 + 264 WP_006247805.1 hypothetical protein -
BG588_RS09855 1884790..1885500 + 711 WP_006253312.1 tape measure protein -
BG588_RS09860 1885478..1885768 + 291 Protein_1905 C40 family peptidase -
BG588_RS09865 1885758..1886477 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG588_RS09870 1886699..1887325 + 627 WP_006247807.1 tail assembly protein -
BG588_RS09875 1887374..1887985 + 612 WP_006253310.1 hypothetical protein -
BG588_RS09880 1888096..1888782 + 687 WP_006247808.1 hypothetical protein -
BG588_RS14210 1888792..1888950 + 159 WP_006247809.1 hypothetical protein -
BG588_RS09885 1888959..1889258 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1871240..1895446 24206
- flank IS/Tn - - 1879196..1879888 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67329 WP_006247804.1 NZ_CP017541:1884123-1884392 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67329 NZ_CP017541:1884123-1884392 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67329 WP_006247803.1 NZ_CP017541:1883853-1884119 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67329 NZ_CP017541:1883853-1884119 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References