67311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 884734..885273 Replicon chromosome
Accession NZ_CP017539
Organism Mannheimia haemolytica strain 1454

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG603_RS04730 Protein ID WP_006247804.1
Coordinates 885004..885273 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG603_RS04725 Protein ID WP_006247803.1
Coordinates 884734..885000 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG603_RS04670 880134..880769 - 636 Protein_906 transposase -
BG603_RS04680 880870..881580 - 711 Protein_907 tyrosine-type recombinase/integrase -
BG603_RS04685 881484..881807 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG603_RS04690 881888..882055 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG603_RS04695 882063..882437 - 375 WP_006247798.1 hypothetical protein -
BG603_RS04700 882587..882814 + 228 Protein_911 phage terminase large subunit family protein -
BG603_RS04705 882839..883234 + 396 WP_006247799.1 phage tail protein -
BG603_RS04710 883266..883907 + 642 WP_006247800.1 hypothetical protein -
BG603_RS04715 883990..884391 + 402 WP_006247801.1 hypothetical protein -
BG603_RS04720 884436..884666 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG603_RS04725 884734..885000 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG603_RS04730 885004..885273 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG603_RS04735 885348..885611 + 264 WP_006247805.1 hypothetical protein -
BG603_RS04740 885671..886381 + 711 WP_006253312.1 tape measure protein -
BG603_RS04745 886359..886649 + 291 Protein_920 C40 family peptidase -
BG603_RS04750 886639..887358 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG603_RS04755 887580..888206 + 627 WP_006247807.1 tail assembly protein -
BG603_RS04760 888255..888866 + 612 WP_006253310.1 hypothetical protein -
BG603_RS04765 888977..889663 + 687 WP_006247808.1 hypothetical protein -
BG603_RS14330 889673..889831 + 159 WP_006247809.1 hypothetical protein -
BG603_RS04770 889840..890139 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 866165..934148 67983
- flank IS/Tn - - 880077..880769 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67311 WP_006247804.1 NZ_CP017539:885004-885273 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67311 NZ_CP017539:885004-885273 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67311 WP_006247803.1 NZ_CP017539:884734-885000 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67311 NZ_CP017539:884734-885000 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References