Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1080667..1081315 Replicon chromosome
Accession NZ_CP017534
Organism Mannheimia haemolytica strain 1503

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG587_RS05460 Protein ID WP_006251221.1
Coordinates 1080667..1080843 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG587_RS05465 Protein ID WP_006251222.1
Coordinates 1080899..1081315 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG587_RS05435 1075985..1078480 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG587_RS05445 1079025..1079483 - 459 WP_006251218.1 hypothetical protein -
BG587_RS05450 1079652..1079885 + 234 WP_020824316.1 hypothetical protein -
BG587_RS05455 1079900..1080571 - 672 WP_006251220.1 hypothetical protein -
BG587_RS05460 1080667..1080843 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG587_RS05465 1080899..1081315 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG587_RS05470 1081355..1081837 - 483 WP_006251223.1 phage tail protein -
BG587_RS05475 1081841..1082221 - 381 WP_006251224.1 hypothetical protein -
BG587_RS05480 1082218..1082586 - 369 WP_006251225.1 hypothetical protein -
BG587_RS05485 1082588..1082932 - 345 WP_006251226.1 hypothetical protein -
BG587_RS05490 1082932..1083309 - 378 WP_006251227.1 hypothetical protein -
BG587_RS05495 1083312..1083554 - 243 WP_061888482.1 hypothetical protein -
BG587_RS05500 1083566..1084555 - 990 WP_006251229.1 encapsulin -
BG587_RS05505 1084570..1085004 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67272 WP_006251221.1 NZ_CP017534:1080667-1080843 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67272 NZ_CP017534:1080667-1080843 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67272 WP_006251222.1 NZ_CP017534:1080899-1081315 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67272 NZ_CP017534:1080899-1081315 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References