Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1807446..1807985 Replicon chromosome
Accession NZ_CP017533
Organism Mannheimia haemolytica strain 1506

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG596_RS09275 Protein ID WP_006247804.1
Coordinates 1807716..1807985 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG596_RS09270 Protein ID WP_006247803.1
Coordinates 1807446..1807712 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG596_RS09215 1802846..1803481 - 636 Protein_1793 transposase -
BG596_RS09225 1803582..1804292 - 711 Protein_1794 tyrosine-type recombinase/integrase -
BG596_RS09230 1804196..1804519 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG596_RS09235 1804600..1804767 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG596_RS09240 1804775..1805149 - 375 WP_006247798.1 hypothetical protein -
BG596_RS09245 1805299..1805526 + 228 Protein_1798 phage terminase large subunit family protein -
BG596_RS09250 1805551..1805946 + 396 WP_006247799.1 phage tail protein -
BG596_RS09255 1805978..1806619 + 642 WP_006247800.1 hypothetical protein -
BG596_RS09260 1806702..1807103 + 402 WP_006247801.1 hypothetical protein -
BG596_RS09265 1807148..1807378 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG596_RS09270 1807446..1807712 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG596_RS09275 1807716..1807985 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG596_RS09280 1808060..1808323 + 264 WP_006247805.1 hypothetical protein -
BG596_RS09285 1808383..1809093 + 711 WP_006253312.1 tape measure protein -
BG596_RS09290 1809071..1809361 + 291 Protein_1807 C40 family peptidase -
BG596_RS09295 1809351..1810070 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG596_RS09300 1810292..1810918 + 627 WP_006247807.1 tail assembly protein -
BG596_RS09305 1810967..1811578 + 612 WP_147010781.1 phage tail protein -
BG596_RS09310 1811689..1812375 + 687 WP_006247808.1 hypothetical protein -
BG596_RS13625 1812385..1812543 + 159 WP_006247809.1 hypothetical protein -
BG596_RS09315 1812552..1812851 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1793539..1819039 25500
- flank IS/Tn - - 1802789..1803481 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67266 WP_006247804.1 NZ_CP017533:1807716-1807985 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67266 NZ_CP017533:1807716-1807985 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67266 WP_006247803.1 NZ_CP017533:1807446-1807712 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67266 NZ_CP017533:1807446-1807712 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References