Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1539544..1540192 Replicon chromosome
Accession NZ_CP017533
Organism Mannheimia haemolytica strain 1506

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG596_RS07675 Protein ID WP_006251221.1
Coordinates 1539544..1539720 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG596_RS07680 Protein ID WP_006251222.1
Coordinates 1539776..1540192 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG596_RS07650 1534862..1537357 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG596_RS07660 1537902..1538360 - 459 WP_006251218.1 hypothetical protein -
BG596_RS07665 1538529..1538762 + 234 WP_020824316.1 hypothetical protein -
BG596_RS07670 1538777..1539448 - 672 WP_006251220.1 hypothetical protein -
BG596_RS07675 1539544..1539720 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG596_RS07680 1539776..1540192 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG596_RS07685 1540232..1540714 - 483 WP_006251223.1 phage tail protein -
BG596_RS07690 1540718..1541098 - 381 WP_006251224.1 hypothetical protein -
BG596_RS07695 1541095..1541463 - 369 WP_006251225.1 hypothetical protein -
BG596_RS07700 1541465..1541809 - 345 WP_006251226.1 hypothetical protein -
BG596_RS07705 1541809..1542186 - 378 WP_006251227.1 hypothetical protein -
BG596_RS13575 1542189..1542494 - 306 WP_015587049.1 hypothetical protein -
BG596_RS07710 1542506..1543495 - 990 WP_006251229.1 encapsulin -
BG596_RS07715 1543510..1543944 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1506146..1590967 84821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67264 WP_006251221.1 NZ_CP017533:1539544-1539720 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67264 NZ_CP017533:1539544-1539720 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67264 WP_006251222.1 NZ_CP017533:1539776-1540192 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67264 NZ_CP017533:1539776-1540192 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References