Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1697648..1698288 Replicon chromosome
Accession NZ_CP017532
Organism Mannheimia haemolytica strain 1512

Toxin (Protein)


Gene name hicA Uniprot ID A0A378NFX7
Locus tag BG583_RS08785 Protein ID WP_006250075.1
Coordinates 1698106..1698288 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A378NFW9
Locus tag BG583_RS08780 Protein ID WP_006250074.1
Coordinates 1697648..1698067 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG583_RS08755 1693195..1694001 + 807 WP_006248821.1 tryptophan synthase subunit alpha -
BG583_RS08760 1694051..1695457 + 1407 WP_006253513.1 YdgA family protein -
BG583_RS08765 1695524..1696530 - 1007 Protein_1703 IS481 family transposase -
BG583_RS08775 1696668..1697312 - 645 WP_006253274.1 tyrosine-type recombinase/integrase -
BG583_RS08780 1697648..1698067 - 420 WP_006250074.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG583_RS08785 1698106..1698288 - 183 WP_006250075.1 type II toxin-antitoxin system HicA family toxin Toxin
BG583_RS08790 1698420..1698905 - 486 WP_015484250.1 hypothetical protein -
BG583_RS08795 1698910..1699290 - 381 WP_006248823.1 hypothetical protein -
BG583_RS08800 1699365..1700048 - 684 WP_006248824.1 helix-turn-helix transcriptional regulator -
BG583_RS08805 1700179..1700379 + 201 WP_006248825.1 helix-turn-helix domain-containing protein -
BG583_RS14390 1700400..1701467 + 1068 WP_006253284.1 hypothetical protein -
BG583_RS14395 1701477..1701635 + 159 WP_006247809.1 hypothetical protein -
BG583_RS08820 1701644..1701943 - 300 WP_006247810.1 XRE family transcriptional regulator -
BG583_RS08825 1701915..1702304 - 390 WP_015484247.1 type II toxin-antitoxin system RelE/ParE family toxin -
BG583_RS08830 1702448..1702741 + 294 WP_006247812.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-96)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.03 Da        Isoelectric Point: 10.3446

>T67257 WP_006250075.1 NZ_CP017532:c1698288-1698106 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK

Download         Length: 183 bp

>T67257 NZ_CP017532:c1698288-1698106 [Mannheimia haemolytica]
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15938.30 Da        Isoelectric Point: 4.6963

>AT67257 WP_006250074.1 NZ_CP017532:c1698067-1697648 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH

Download         Length: 420 bp

>AT67257 NZ_CP017532:c1698067-1697648 [Mannheimia haemolytica]
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATATCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGCAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACACT
TTACTATTCTCCCTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378NFX7

Antitoxin

Source ID Structure
AlphaFold DB A0A378NFW9

References