67256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1338427..1339075 Replicon chromosome
Accession NZ_CP017532
Organism Mannheimia haemolytica strain 1512

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG583_RS06960 Protein ID WP_006251221.1
Coordinates 1338899..1339075 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG583_RS06955 Protein ID WP_006251222.1
Coordinates 1338427..1338843 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG583_RS06915 1334729..1335163 + 435 WP_006251230.1 hypothetical protein -
BG583_RS06920 1335178..1336167 + 990 WP_006251229.1 encapsulin -
BG583_RS06925 1336179..1336430 + 252 WP_015484272.1 hypothetical protein -
BG583_RS06930 1336433..1336810 + 378 WP_006251227.1 hypothetical protein -
BG583_RS06935 1336810..1337154 + 345 WP_006251226.1 hypothetical protein -
BG583_RS06940 1337156..1337524 + 369 WP_006251225.1 hypothetical protein -
BG583_RS06945 1337521..1337901 + 381 WP_006251224.1 hypothetical protein -
BG583_RS06950 1337905..1338387 + 483 WP_006251223.1 phage tail protein -
BG583_RS06955 1338427..1338843 - 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG583_RS06960 1338899..1339075 - 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG583_RS06965 1339171..1339842 + 672 WP_006251220.1 hypothetical protein -
BG583_RS06970 1339857..1340090 - 234 WP_020824316.1 hypothetical protein -
BG583_RS06975 1340259..1340717 + 459 WP_006251218.1 hypothetical protein -
BG583_RS06985 1341262..1343757 + 2496 WP_006251216.1 phage tail length tape measure family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1307269..1359209 51940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67256 WP_006251221.1 NZ_CP017532:c1339075-1338899 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67256 NZ_CP017532:c1339075-1338899 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67256 WP_006251222.1 NZ_CP017532:c1338843-1338427 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67256 NZ_CP017532:c1338843-1338427 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References