Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1835623..1836162 Replicon chromosome
Accession NZ_CP017529
Organism Mannheimia haemolytica strain 1560

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG600_RS09500 Protein ID WP_006247804.1
Coordinates 1835893..1836162 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG600_RS09495 Protein ID WP_006247803.1
Coordinates 1835623..1835889 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG600_RS09450 1831164..1831451 + 288 WP_006247821.1 50S ribosomal protein L25 -
BG600_RS09455 1831610..1832650 - 1041 WP_006247822.1 tyrosine-type recombinase/integrase -
BG600_RS09460 1832672..1832893 - 222 WP_006247823.1 DUF4224 domain-containing protein -
BG600_RS09465 1832943..1833326 - 384 WP_006253376.1 hypothetical protein -
BG600_RS09470 1833476..1833703 + 228 Protein_1841 phage terminase large subunit family protein -
BG600_RS09475 1833728..1834123 + 396 WP_006247799.1 phage tail protein -
BG600_RS09480 1834155..1834796 + 642 WP_006247800.1 hypothetical protein -
BG600_RS09485 1834879..1835280 + 402 WP_006247801.1 hypothetical protein -
BG600_RS09490 1835325..1835555 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG600_RS09495 1835623..1835889 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG600_RS09500 1835893..1836162 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG600_RS09505 1836237..1836500 + 264 WP_006247805.1 hypothetical protein -
BG600_RS09510 1836560..1837270 + 711 WP_006253312.1 tape measure protein -
BG600_RS09515 1837248..1837538 + 291 Protein_1850 C40 family peptidase -
BG600_RS09520 1837528..1838247 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG600_RS09525 1838469..1839095 + 627 WP_006247807.1 tail assembly protein -
BG600_RS09530 1839144..1839755 + 612 WP_006253310.1 hypothetical protein -
BG600_RS09535 1839866..1840552 + 687 WP_006247808.1 hypothetical protein -
BG600_RS13840 1840562..1840720 + 159 WP_006247809.1 hypothetical protein -
BG600_RS09540 1840729..1841028 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67235 WP_006247804.1 NZ_CP017529:1835893-1836162 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67235 NZ_CP017529:1835893-1836162 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67235 WP_006247803.1 NZ_CP017529:1835623-1835889 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67235 NZ_CP017529:1835623-1835889 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References