Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1822091..1822630 Replicon chromosome
Accession NZ_CP017528
Organism Mannheimia haemolytica strain 1561

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG579_RS09415 Protein ID WP_006247804.1
Coordinates 1822361..1822630 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG579_RS09410 Protein ID WP_006247803.1
Coordinates 1822091..1822357 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG579_RS09355 1817491..1818126 - 636 Protein_1816 transposase -
BG579_RS09365 1818227..1818937 - 711 Protein_1817 tyrosine-type recombinase/integrase -
BG579_RS09370 1818841..1819164 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG579_RS09375 1819245..1819412 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG579_RS09380 1819420..1819794 - 375 WP_006247798.1 hypothetical protein -
BG579_RS09385 1819944..1820171 + 228 Protein_1821 phage terminase large subunit family protein -
BG579_RS09390 1820196..1820591 + 396 WP_006247799.1 phage tail protein -
BG579_RS09395 1820623..1821264 + 642 WP_006247800.1 hypothetical protein -
BG579_RS09400 1821347..1821748 + 402 WP_006247801.1 hypothetical protein -
BG579_RS09405 1821793..1822023 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG579_RS09410 1822091..1822357 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG579_RS09415 1822361..1822630 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG579_RS09420 1822705..1822968 + 264 WP_006247805.1 hypothetical protein -
BG579_RS09425 1823028..1823738 + 711 WP_006253312.1 tape measure protein -
BG579_RS09430 1823716..1824006 + 291 Protein_1830 C40 family peptidase -
BG579_RS09435 1823996..1824715 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG579_RS09440 1824937..1825563 + 627 WP_006247807.1 tail assembly protein -
BG579_RS09445 1825612..1826223 + 612 WP_147010781.1 phage tail protein -
BG579_RS09450 1826334..1827020 + 687 WP_006247808.1 hypothetical protein -
BG579_RS14000 1827030..1827188 + 159 WP_006247809.1 hypothetical protein -
BG579_RS09455 1827197..1827496 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1808184..1833684 25500
- flank IS/Tn - - 1817434..1818126 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67227 WP_006247804.1 NZ_CP017528:1822361-1822630 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67227 NZ_CP017528:1822361-1822630 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67227 WP_006247803.1 NZ_CP017528:1822091-1822357 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67227 NZ_CP017528:1822091-1822357 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References