Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1637659..1638198 Replicon chromosome
Accession NZ_CP017527
Organism Mannheimia haemolytica strain 1563

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG590_RS08455 Protein ID WP_006247804.1
Coordinates 1637659..1637928 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG590_RS08460 Protein ID WP_006247803.1
Coordinates 1637932..1638198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG590_RS08415 1632793..1633092 + 300 WP_006247810.1 XRE family transcriptional regulator -
BG590_RS13985 1633101..1633259 - 159 WP_006247809.1 hypothetical protein -
BG590_RS08420 1633269..1633955 - 687 WP_006247808.1 hypothetical protein -
BG590_RS08425 1634066..1634677 - 612 WP_006253310.1 hypothetical protein -
BG590_RS08430 1634726..1635352 - 627 WP_006247807.1 tail assembly protein -
BG590_RS08435 1635574..1636293 - 720 WP_006247806.1 preprotein translocase subunit YajC -
BG590_RS08440 1636283..1636573 - 291 Protein_1640 C40 family peptidase -
BG590_RS08445 1636551..1637261 - 711 WP_006253312.1 tape measure protein -
BG590_RS08450 1637321..1637584 - 264 WP_006247805.1 hypothetical protein -
BG590_RS08455 1637659..1637928 - 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG590_RS08460 1637932..1638198 - 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG590_RS08465 1638266..1638496 - 231 WP_006247802.1 DUF4035 domain-containing protein -
BG590_RS08470 1638541..1638942 - 402 WP_006247801.1 hypothetical protein -
BG590_RS08475 1639025..1639666 - 642 WP_006247800.1 hypothetical protein -
BG590_RS08480 1639698..1640093 - 396 WP_006247799.1 phage tail protein -
BG590_RS08485 1640118..1640345 - 228 Protein_1649 phage terminase large subunit family protein -
BG590_RS08490 1640495..1640869 + 375 WP_006247798.1 hypothetical protein -
BG590_RS08495 1640877..1641044 + 168 WP_006253314.1 DNA cytosine methyltransferase -
BG590_RS08500 1641125..1641448 + 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG590_RS08505 1641352..1642062 + 711 Protein_1653 tyrosine-type recombinase/integrase -
BG590_RS08515 1642163..1642798 + 636 Protein_1654 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1571008..1664720 93712
- flank IS/Tn - - 1642163..1642855 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67218 WP_006247804.1 NZ_CP017527:c1637928-1637659 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67218 NZ_CP017527:c1637928-1637659 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67218 WP_006247803.1 NZ_CP017527:c1638198-1637932 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67218 NZ_CP017527:c1638198-1637932 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References