Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1907095..1907634 Replicon chromosome
Accession NZ_CP017524
Organism Mannheimia haemolytica strain 1576

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG595_RS09910 Protein ID WP_006247804.1
Coordinates 1907365..1907634 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG595_RS09905 Protein ID WP_006247803.1
Coordinates 1907095..1907361 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG595_RS09850 1902495..1903130 - 636 Protein_1921 transposase -
BG595_RS09860 1903231..1903941 - 711 Protein_1922 tyrosine-type recombinase/integrase -
BG595_RS09865 1903845..1904168 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG595_RS09870 1904249..1904416 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG595_RS09875 1904424..1904798 - 375 WP_006247798.1 hypothetical protein -
BG595_RS09880 1904948..1905175 + 228 Protein_1926 phage terminase large subunit family protein -
BG595_RS09885 1905200..1905595 + 396 WP_006247799.1 phage tail protein -
BG595_RS09890 1905627..1906268 + 642 WP_006247800.1 hypothetical protein -
BG595_RS09895 1906351..1906752 + 402 WP_006247801.1 hypothetical protein -
BG595_RS09900 1906797..1907027 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG595_RS09905 1907095..1907361 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG595_RS09910 1907365..1907634 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG595_RS09915 1907709..1907972 + 264 WP_006247805.1 hypothetical protein -
BG595_RS09920 1908032..1908742 + 711 WP_006253312.1 tape measure protein -
BG595_RS09925 1908720..1909010 + 291 Protein_1935 C40 family peptidase -
BG595_RS09930 1909000..1909719 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG595_RS09935 1909941..1910567 + 627 WP_006247807.1 tail assembly protein -
BG595_RS09940 1910616..1911227 + 612 WP_006253310.1 hypothetical protein -
BG595_RS09945 1911338..1912024 + 687 WP_006247808.1 hypothetical protein -
BG595_RS14255 1912034..1912192 + 159 WP_006247809.1 hypothetical protein -
BG595_RS09950 1912201..1912500 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1893188..1917262 24074
- flank IS/Tn - - 1902438..1903130 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67197 WP_006247804.1 NZ_CP017524:1907365-1907634 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67197 NZ_CP017524:1907365-1907634 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67197 WP_006247803.1 NZ_CP017524:1907095-1907361 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67197 NZ_CP017524:1907095-1907361 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References