Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1813479..1814018 Replicon chromosome
Accession NZ_CP017523
Organism Mannheimia haemolytica strain 1582

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG606_RS09365 Protein ID WP_006247804.1
Coordinates 1813749..1814018 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG606_RS09360 Protein ID WP_006247803.1
Coordinates 1813479..1813745 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG606_RS09305 1808878..1809513 - 636 Protein_1799 transposase -
BG606_RS09315 1809615..1810325 - 711 Protein_1800 tyrosine-type recombinase/integrase -
BG606_RS09320 1810229..1810552 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG606_RS09325 1810633..1810800 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG606_RS09330 1810808..1811182 - 375 WP_006247798.1 hypothetical protein -
BG606_RS09335 1811332..1811559 + 228 Protein_1804 phage terminase large subunit family protein -
BG606_RS09340 1811584..1811979 + 396 WP_006247799.1 phage tail protein -
BG606_RS09345 1812011..1812652 + 642 WP_006247800.1 hypothetical protein -
BG606_RS09350 1812735..1813136 + 402 WP_006247801.1 hypothetical protein -
BG606_RS09355 1813181..1813411 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG606_RS09360 1813479..1813745 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG606_RS09365 1813749..1814018 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG606_RS09370 1814093..1814356 + 264 WP_006247805.1 hypothetical protein -
BG606_RS09375 1814416..1815126 + 711 WP_006253312.1 tape measure protein -
BG606_RS09380 1815104..1815394 + 291 Protein_1813 C40 family peptidase -
BG606_RS09385 1815384..1816103 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG606_RS09390 1816325..1816951 + 627 WP_006247807.1 tail assembly protein -
BG606_RS09395 1817000..1817611 + 612 WP_006253310.1 hypothetical protein -
BG606_RS09400 1817722..1818408 + 687 WP_006247808.1 hypothetical protein -
BG606_RS13700 1818418..1818576 + 159 WP_006247809.1 hypothetical protein -
BG606_RS09405 1818585..1818884 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1800865..1825072 24207
- flank IS/Tn - - 1808821..1809513 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67191 WP_006247804.1 NZ_CP017523:1813749-1814018 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67191 NZ_CP017523:1813749-1814018 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67191 WP_006247803.1 NZ_CP017523:1813479-1813745 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67191 NZ_CP017523:1813479-1813745 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References