Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1901736..1902275 Replicon chromosome
Accession NZ_CP017521
Organism Mannheimia haemolytica strain 1584

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG594_RS09930 Protein ID WP_006247804.1
Coordinates 1902006..1902275 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG594_RS09925 Protein ID WP_006247803.1
Coordinates 1901736..1902002 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG594_RS09870 1897136..1897771 - 636 Protein_1919 transposase -
BG594_RS09880 1897872..1898582 - 711 Protein_1920 tyrosine-type recombinase/integrase -
BG594_RS09885 1898486..1898809 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG594_RS09890 1898890..1899057 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG594_RS09895 1899065..1899439 - 375 WP_006247798.1 hypothetical protein -
BG594_RS09900 1899589..1899816 + 228 Protein_1924 phage terminase large subunit family protein -
BG594_RS09905 1899841..1900236 + 396 WP_006247799.1 phage tail protein -
BG594_RS09910 1900268..1900909 + 642 WP_006247800.1 hypothetical protein -
BG594_RS09915 1900992..1901393 + 402 WP_006247801.1 hypothetical protein -
BG594_RS09920 1901438..1901668 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG594_RS09925 1901736..1902002 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG594_RS09930 1902006..1902275 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG594_RS09935 1902350..1902613 + 264 WP_006247805.1 hypothetical protein -
BG594_RS09940 1902673..1903383 + 711 WP_006253312.1 tape measure protein -
BG594_RS09945 1903361..1903651 + 291 Protein_1933 C40 family peptidase -
BG594_RS09950 1903641..1904360 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG594_RS09955 1904582..1905208 + 627 WP_006247807.1 tail assembly protein -
BG594_RS09960 1905257..1905868 + 612 WP_006253310.1 hypothetical protein -
BG594_RS09965 1905979..1906665 + 687 WP_006247808.1 hypothetical protein -
BG594_RS14305 1906675..1906833 + 159 WP_006247809.1 hypothetical protein -
BG594_RS09970 1906842..1907141 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1887829..1911903 24074
- flank IS/Tn - - 1897079..1897771 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67176 WP_006247804.1 NZ_CP017521:1902006-1902275 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67176 NZ_CP017521:1902006-1902275 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67176 WP_006247803.1 NZ_CP017521:1901736-1902002 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67176 NZ_CP017521:1901736-1902002 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References