Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1313108..1313756 Replicon chromosome
Accession NZ_CP017521
Organism Mannheimia haemolytica strain 1584

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG594_RS06800 Protein ID WP_006251221.1
Coordinates 1313580..1313756 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG594_RS06795 Protein ID WP_006251222.1
Coordinates 1313108..1313524 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG594_RS06755 1309383..1309817 + 435 WP_006251230.1 hypothetical protein -
BG594_RS06760 1309832..1310821 + 990 WP_006251229.1 encapsulin -
BG594_RS14225 1310833..1311111 + 279 WP_021279981.1 hypothetical protein -
BG594_RS06770 1311114..1311491 + 378 WP_006251227.1 hypothetical protein -
BG594_RS06775 1311491..1311835 + 345 WP_006251226.1 hypothetical protein -
BG594_RS06780 1311837..1312205 + 369 WP_006251225.1 hypothetical protein -
BG594_RS06785 1312202..1312582 + 381 WP_006251224.1 hypothetical protein -
BG594_RS06790 1312586..1313068 + 483 WP_006251223.1 phage tail protein -
BG594_RS06795 1313108..1313524 - 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG594_RS06800 1313580..1313756 - 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG594_RS06805 1313852..1314523 + 672 WP_006251220.1 hypothetical protein -
BG594_RS06810 1314538..1314771 - 234 WP_020824316.1 hypothetical protein -
BG594_RS06815 1314940..1315398 + 459 WP_006251218.1 hypothetical protein -
BG594_RS06825 1315943..1318438 + 2496 WP_006251216.1 phage tail length tape measure family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1283934..1338015 54081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67174 WP_006251221.1 NZ_CP017521:c1313756-1313580 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67174 NZ_CP017521:c1313756-1313580 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67174 WP_006251222.1 NZ_CP017521:c1313524-1313108 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67174 NZ_CP017521:c1313524-1313108 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References