Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1927094..1927633 Replicon chromosome
Accession NZ_CP017520
Organism Mannheimia haemolytica strain 1609

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG591_RS10090 Protein ID WP_006247804.1
Coordinates 1927364..1927633 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG591_RS10085 Protein ID WP_006247803.1
Coordinates 1927094..1927360 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG591_RS10030 1922494..1923129 - 636 Protein_1956 transposase -
BG591_RS10040 1923230..1923940 - 711 Protein_1957 tyrosine-type recombinase/integrase -
BG591_RS10045 1923844..1924167 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG591_RS10050 1924248..1924415 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG591_RS10055 1924423..1924797 - 375 WP_006247798.1 hypothetical protein -
BG591_RS10060 1924947..1925174 + 228 Protein_1961 phage terminase large subunit family protein -
BG591_RS10065 1925199..1925594 + 396 WP_006247799.1 phage tail protein -
BG591_RS10070 1925626..1926267 + 642 WP_006247800.1 hypothetical protein -
BG591_RS10075 1926350..1926751 + 402 WP_006247801.1 hypothetical protein -
BG591_RS10080 1926796..1927026 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG591_RS10085 1927094..1927360 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG591_RS10090 1927364..1927633 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG591_RS10095 1927708..1927971 + 264 WP_006247805.1 hypothetical protein -
BG591_RS10100 1928031..1928741 + 711 WP_006253312.1 tape measure protein -
BG591_RS10105 1928719..1929009 + 291 Protein_1970 C40 family peptidase -
BG591_RS10110 1928999..1929718 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG591_RS10115 1929940..1930566 + 627 WP_006247807.1 tail assembly protein -
BG591_RS10120 1930615..1931226 + 612 WP_006253310.1 hypothetical protein -
BG591_RS10125 1931337..1932023 + 687 WP_006247808.1 hypothetical protein -
BG591_RS14500 1932033..1932191 + 159 WP_006247809.1 hypothetical protein -
BG591_RS10130 1932200..1932499 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1913187..1938687 25500
- flank IS/Tn - - 1922437..1923129 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67168 WP_006247804.1 NZ_CP017520:1927364-1927633 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67168 NZ_CP017520:1927364-1927633 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67168 WP_006247803.1 NZ_CP017520:1927094-1927360 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67168 NZ_CP017520:1927094-1927360 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References