Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1632518..1633166 Replicon chromosome
Accession NZ_CP017520
Organism Mannheimia haemolytica strain 1609

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG591_RS08320 Protein ID WP_006251221.1
Coordinates 1632518..1632694 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG591_RS08325 Protein ID WP_006251222.1
Coordinates 1632750..1633166 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG591_RS08295 1627836..1630331 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG591_RS08305 1630876..1631334 - 459 WP_006251218.1 hypothetical protein -
BG591_RS08310 1631503..1631736 + 234 WP_020824316.1 hypothetical protein -
BG591_RS08315 1631751..1632422 - 672 WP_006251220.1 hypothetical protein -
BG591_RS08320 1632518..1632694 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG591_RS08325 1632750..1633166 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG591_RS08330 1633206..1633688 - 483 WP_006251223.1 phage tail protein -
BG591_RS08335 1633692..1634072 - 381 WP_006251224.1 hypothetical protein -
BG591_RS08340 1634069..1634437 - 369 WP_006251225.1 hypothetical protein -
BG591_RS08345 1634439..1634783 - 345 WP_006251226.1 hypothetical protein -
BG591_RS08350 1634783..1635160 - 378 WP_006251227.1 hypothetical protein -
BG591_RS14440 1635163..1635441 - 279 WP_021279981.1 hypothetical protein -
BG591_RS08360 1635453..1636442 - 990 WP_006251229.1 encapsulin -
BG591_RS08365 1636457..1636891 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1615428..1733251 117823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67167 WP_006251221.1 NZ_CP017520:1632518-1632694 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67167 NZ_CP017520:1632518-1632694 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67167 WP_006251222.1 NZ_CP017520:1632750-1633166 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67167 NZ_CP017520:1632750-1633166 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References