67161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1863103..1863642 Replicon chromosome
Accession NZ_CP017519
Organism Mannheimia haemolytica strain 22549

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG610_RS09655 Protein ID WP_006247804.1
Coordinates 1863373..1863642 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG610_RS09650 Protein ID WP_006247803.1
Coordinates 1863103..1863369 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG610_RS09595 1858503..1859138 - 636 Protein_1875 transposase -
BG610_RS09605 1859239..1859949 - 711 Protein_1876 tyrosine-type recombinase/integrase -
BG610_RS09610 1859853..1860176 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG610_RS09615 1860257..1860424 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG610_RS09620 1860432..1860806 - 375 WP_006247798.1 hypothetical protein -
BG610_RS09625 1860956..1861183 + 228 Protein_1880 phage terminase large subunit family protein -
BG610_RS09630 1861208..1861603 + 396 WP_006247799.1 phage tail protein -
BG610_RS09635 1861635..1862276 + 642 WP_006247800.1 hypothetical protein -
BG610_RS09640 1862359..1862760 + 402 WP_006247801.1 hypothetical protein -
BG610_RS09645 1862805..1863035 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG610_RS09650 1863103..1863369 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG610_RS09655 1863373..1863642 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG610_RS09660 1863717..1863980 + 264 WP_006247805.1 hypothetical protein -
BG610_RS09665 1864040..1864750 + 711 WP_006253312.1 tape measure protein -
BG610_RS09670 1864728..1865018 + 291 Protein_1889 C40 family peptidase -
BG610_RS09675 1865008..1865727 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG610_RS09680 1865949..1866575 + 627 WP_006247807.1 tail assembly protein -
BG610_RS09685 1866624..1867235 + 612 WP_006253310.1 hypothetical protein -
BG610_RS09690 1867346..1868032 + 687 WP_006247808.1 hypothetical protein -
BG610_RS14050 1868042..1868200 + 159 WP_006247809.1 hypothetical protein -
BG610_RS09695 1868209..1868508 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1850490..1874696 24206
- flank IS/Tn - - 1858446..1859138 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67161 WP_006247804.1 NZ_CP017519:1863373-1863642 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67161 NZ_CP017519:1863373-1863642 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67161 WP_006247803.1 NZ_CP017519:1863103-1863369 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67161 NZ_CP017519:1863103-1863369 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References