Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
Location | 1981983..1982623 | Replicon | chromosome |
Accession | NZ_CP017514 | ||
Organism | Mannheimia haemolytica strain 23311 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A378NFX7 |
Locus tag | BG573_RS09790 | Protein ID | WP_006250075.1 |
Coordinates | 1981983..1982165 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A378NET2 |
Locus tag | BG573_RS09795 | Protein ID | WP_006250984.1 |
Coordinates | 1982204..1982623 (+) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BG573_RS09755 | 1977554..1978600 | - | 1047 | WP_020824125.1 | conserved phage C-terminal domain-containing protein | - |
BG573_RS09760 | 1978597..1979436 | - | 840 | WP_006252350.1 | Rha family transcriptional regulator | - |
BG573_RS09765 | 1979612..1979872 | - | 261 | WP_006252483.1 | hypothetical protein | - |
BG573_RS09770 | 1979893..1980093 | - | 201 | WP_006248825.1 | helix-turn-helix domain-containing protein | - |
BG573_RS09775 | 1980224..1980907 | + | 684 | WP_006252485.1 | helix-turn-helix transcriptional regulator | - |
BG573_RS09780 | 1980982..1981362 | + | 381 | WP_006248823.1 | hypothetical protein | - |
BG573_RS09785 | 1981367..1981852 | + | 486 | WP_006252741.1 | hypothetical protein | - |
BG573_RS09790 | 1981983..1982165 | + | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
BG573_RS09795 | 1982204..1982623 | + | 420 | WP_006250984.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
BG573_RS09800 | 1982690..1982995 | - | 306 | WP_006250985.1 | HigA family addiction module antidote protein | - |
BG573_RS09805 | 1983004..1983279 | - | 276 | WP_006250986.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
BG573_RS09810 | 1983569..1983799 | + | 231 | WP_006250987.1 | hypothetical protein | - |
BG573_RS09815 | 1984278..1984601 | - | 324 | WP_006250988.1 | hypothetical protein | - |
BG573_RS09820 | 1984794..1984979 | + | 186 | WP_020824222.1 | hypothetical protein | - |
BG573_RS12775 | 1984963..1985127 | + | 165 | WP_020824223.1 | hypothetical protein | - |
BG573_RS09825 | 1985133..1985591 | + | 459 | WP_006253113.1 | single-stranded DNA-binding protein | - |
BG573_RS09830 | 1985627..1985986 | + | 360 | WP_006250991.1 | hypothetical protein | - |
BG573_RS09835 | 1986058..1986861 | + | 804 | WP_020824224.1 | DUF2303 family protein | - |
BG573_RS09840 | 1986955..1987389 | + | 435 | WP_020824225.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1920993..1992971 | 71978 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T67127 WP_006250075.1 NZ_CP017514:1981983-1982165 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
>T67127 NZ_CP017514:1981983-1982165 [Mannheimia haemolytica]
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15957.34 Da Isoelectric Point: 4.6983
>AT67127 WP_006250984.1 NZ_CP017514:1982204-1982623 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
Download Length: 420 bp
>AT67127 NZ_CP017514:1982204-1982623 [Mannheimia haemolytica]
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATACCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGTAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACGCT
TTACTATTCTCCCTCACTAA
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATACCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGTAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACGCT
TTACTATTCTCCCTCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378NFX7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378NET2 |