Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2292289..2292937 | Replicon | chromosome |
Accession | NZ_CP017511 | ||
Organism | Mannheimia haemolytica strain 23570 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A249A099 |
Locus tag | BG555_RS11685 | Protein ID | WP_006251221.1 |
Coordinates | 2292761..2292937 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A248ZZL6 |
Locus tag | BG555_RS11680 | Protein ID | WP_006251222.1 |
Coordinates | 2292289..2292705 (-) | Length | 139 a.a. |
Genomic Context
Location: 2288612..2289046 (435 bp)
Type: Others
Protein ID: WP_006251230.1
Type: Others
Protein ID: WP_006251230.1
Location: 2289061..2290047 (987 bp)
Type: Others
Protein ID: WP_062627922.1
Type: Others
Protein ID: WP_062627922.1
Location: 2290059..2290292 (234 bp)
Type: Others
Protein ID: WP_075271287.1
Type: Others
Protein ID: WP_075271287.1
Location: 2290295..2290672 (378 bp)
Type: Others
Protein ID: WP_006251227.1
Type: Others
Protein ID: WP_006251227.1
Location: 2290672..2291016 (345 bp)
Type: Others
Protein ID: WP_006251226.1
Type: Others
Protein ID: WP_006251226.1
Location: 2291018..2291386 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Type: Others
Protein ID: WP_006251225.1
Location: 2291383..2291763 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Type: Others
Protein ID: WP_006251224.1
Location: 2291767..2292249 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Type: Others
Protein ID: WP_006251223.1
Location: 2293034..2293705 (672 bp)
Type: Others
Protein ID: WP_006251220.1
Type: Others
Protein ID: WP_006251220.1
Location: 2294122..2294580 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Type: Others
Protein ID: WP_006251218.1
Location: 2294648..2295043 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Type: Others
Protein ID: WP_006251217.1
Location: 2295130..2297619 (2490 bp)
Type: Others
Protein ID: WP_147009468.1
Type: Others
Protein ID: WP_147009468.1
Location: 2292289..2292705 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 2292761..2292937 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Type: Toxin
Protein ID: WP_006251221.1
Location: 2293720..2293953 (234 bp)
Type: Others
Protein ID: WP_020824316.1
Type: Others
Protein ID: WP_020824316.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BG555_RS11640 | 2288612..2289046 | + | 435 | WP_006251230.1 | hypothetical protein | - |
BG555_RS11645 | 2289061..2290047 | + | 987 | WP_062627922.1 | encapsulin | - |
BG555_RS11650 | 2290059..2290292 | + | 234 | WP_075271287.1 | hypothetical protein | - |
BG555_RS11655 | 2290295..2290672 | + | 378 | WP_006251227.1 | hypothetical protein | - |
BG555_RS11660 | 2290672..2291016 | + | 345 | WP_006251226.1 | hypothetical protein | - |
BG555_RS11665 | 2291018..2291386 | + | 369 | WP_006251225.1 | hypothetical protein | - |
BG555_RS11670 | 2291383..2291763 | + | 381 | WP_006251224.1 | hypothetical protein | - |
BG555_RS11675 | 2291767..2292249 | + | 483 | WP_006251223.1 | phage tail protein | - |
BG555_RS11680 | 2292289..2292705 | - | 417 | WP_006251222.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
BG555_RS11685 | 2292761..2292937 | - | 177 | WP_006251221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
BG555_RS11690 | 2293034..2293705 | + | 672 | WP_006251220.1 | hypothetical protein | - |
BG555_RS11695 | 2293720..2293953 | - | 234 | WP_020824316.1 | hypothetical protein | - |
BG555_RS11700 | 2294122..2294580 | + | 459 | WP_006251218.1 | hypothetical protein | - |
BG555_RS11705 | 2294648..2295043 | + | 396 | WP_006251217.1 | hypothetical protein | - |
BG555_RS11710 | 2295130..2297619 | + | 2490 | WP_147009468.1 | phage tail length tape measure family protein | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2250635..2306605 | 55970 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6640.79 Da Isoelectric Point: 10.7708
>T67107 WP_006251221.1 NZ_CP017511:c2292937-2292761 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
Download Length: 177 bp
>T67107 NZ_CP017511:c2292937-2292761 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15519.91 Da Isoelectric Point: 4.3508
>AT67107 WP_006251222.1 NZ_CP017511:c2292705-2292289 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG
Download Length: 417 bp
>AT67107 NZ_CP017511:c2292705-2292289 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A249A099 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A248ZZL6 |