Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2292289..2292937 Replicon chromosome
Accession NZ_CP017511
Organism Mannheimia haemolytica strain 23570

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG555_RS11685 Protein ID WP_006251221.1
Coordinates 2292761..2292937 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG555_RS11680 Protein ID WP_006251222.1
Coordinates 2292289..2292705 (-) Length 139 a.a.

Genomic Context


BG555_RS11640BG555_RS11645BG555_RS11650BG555_RS11655BG555_RS11660BG555_RS11665BG555_RS11670BG555_RS11675BG555_RS11690BG555_RS11700BG555_RS11705BG555_RS11710BG555_RS11680BG555_RS11685BG555_RS11695
Location: 2288612..2289046 (435 bp)
Type: Others
Protein ID: WP_006251230.1
Location: 2289061..2290047 (987 bp)
Type: Others
Protein ID: WP_062627922.1
Location: 2290059..2290292 (234 bp)
Type: Others
Protein ID: WP_075271287.1
Location: 2290295..2290672 (378 bp)
Type: Others
Protein ID: WP_006251227.1
Location: 2290672..2291016 (345 bp)
Type: Others
Protein ID: WP_006251226.1
Location: 2291018..2291386 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Location: 2291383..2291763 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Location: 2291767..2292249 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Location: 2293034..2293705 (672 bp)
Type: Others
Protein ID: WP_006251220.1
Location: 2294122..2294580 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Location: 2294648..2295043 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Location: 2295130..2297619 (2490 bp)
Type: Others
Protein ID: WP_147009468.1
Location: 2292289..2292705 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 2292761..2292937 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Location: 2293720..2293953 (234 bp)
Type: Others
Protein ID: WP_020824316.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG555_RS116402288612..2289046+435WP_006251230.1hypothetical protein-
BG555_RS116452289061..2290047+987WP_062627922.1encapsulin-
BG555_RS116502290059..2290292+234WP_075271287.1hypothetical protein-
BG555_RS116552290295..2290672+378WP_006251227.1hypothetical protein-
BG555_RS116602290672..2291016+345WP_006251226.1hypothetical protein-
BG555_RS116652291018..2291386+369WP_006251225.1hypothetical protein-
BG555_RS116702291383..2291763+381WP_006251224.1hypothetical protein-
BG555_RS116752291767..2292249+483WP_006251223.1phage tail protein-
BG555_RS116802292289..2292705-417WP_006251222.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BG555_RS116852292761..2292937-177WP_006251221.1type II toxin-antitoxin system HicA family toxinToxin
BG555_RS116902293034..2293705+672WP_006251220.1hypothetical protein-
BG555_RS116952293720..2293953-234WP_020824316.1hypothetical protein-
BG555_RS117002294122..2294580+459WP_006251218.1hypothetical protein-
BG555_RS117052294648..2295043+396WP_006251217.1hypothetical protein-
BG555_RS117102295130..2297619+2490WP_147009468.1phage tail length tape measure family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2250635..230660555970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67107 WP_006251221.1 NZ_CP017511:c2292937-2292761 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67107 NZ_CP017511:c2292937-2292761 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67107 WP_006251222.1 NZ_CP017511:c2292705-2292289 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67107 NZ_CP017511:c2292705-2292289 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A249A099


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZZL6

References