Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1864804..1865343 Replicon chromosome
Accession NZ_CP017505
Organism Mannheimia haemolytica strain 32619

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG605_RS09680 Protein ID WP_006247804.1
Coordinates 1865074..1865343 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG605_RS09675 Protein ID WP_006247803.1
Coordinates 1864804..1865070 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG605_RS09620 1860204..1860839 - 636 Protein_1878 transposase -
BG605_RS09630 1860940..1861650 - 711 Protein_1879 tyrosine-type recombinase/integrase -
BG605_RS09635 1861554..1861877 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG605_RS09640 1861958..1862125 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG605_RS09645 1862133..1862507 - 375 WP_006247798.1 hypothetical protein -
BG605_RS09650 1862657..1862884 + 228 Protein_1883 phage terminase large subunit family protein -
BG605_RS09655 1862909..1863304 + 396 WP_006247799.1 phage tail protein -
BG605_RS09660 1863336..1863977 + 642 WP_006247800.1 hypothetical protein -
BG605_RS09665 1864060..1864461 + 402 WP_006247801.1 hypothetical protein -
BG605_RS09670 1864506..1864736 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG605_RS09675 1864804..1865070 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG605_RS09680 1865074..1865343 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG605_RS09685 1865418..1865681 + 264 WP_006247805.1 hypothetical protein -
BG605_RS09690 1865741..1866451 + 711 WP_006253312.1 tape measure protein -
BG605_RS09695 1866429..1866719 + 291 Protein_1892 C40 family peptidase -
BG605_RS09700 1866709..1867428 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG605_RS09705 1867650..1868276 + 627 WP_006247807.1 tail assembly protein -
BG605_RS09710 1868325..1868936 + 612 WP_006253310.1 hypothetical protein -
BG605_RS09715 1869047..1869733 + 687 WP_006247808.1 hypothetical protein -
BG605_RS14285 1869743..1869901 + 159 WP_006247809.1 hypothetical protein -
BG605_RS09720 1869910..1870209 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1850897..1915738 64841
- flank IS/Tn - - 1860147..1860839 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67062 WP_006247804.1 NZ_CP017505:1865074-1865343 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67062 NZ_CP017505:1865074-1865343 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67062 WP_006247803.1 NZ_CP017505:1864804-1865070 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67062 NZ_CP017505:1864804-1865070 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References