Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1552214..1552862 Replicon chromosome
Accession NZ_CP017501
Organism Mannheimia haemolytica strain 33041

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG597_RS07770 Protein ID WP_006251221.1
Coordinates 1552214..1552390 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG597_RS07775 Protein ID WP_006251222.1
Coordinates 1552446..1552862 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG597_RS07745 1547532..1550027 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG597_RS07755 1550572..1551030 - 459 WP_006251218.1 hypothetical protein -
BG597_RS07760 1551199..1551432 + 234 WP_020824316.1 hypothetical protein -
BG597_RS07765 1551447..1552118 - 672 WP_006251220.1 hypothetical protein -
BG597_RS07770 1552214..1552390 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG597_RS07775 1552446..1552862 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG597_RS07780 1552902..1553384 - 483 WP_006251223.1 phage tail protein -
BG597_RS07785 1553388..1553768 - 381 WP_006251224.1 hypothetical protein -
BG597_RS07790 1553765..1554133 - 369 WP_006251225.1 hypothetical protein -
BG597_RS07795 1554135..1554479 - 345 WP_006251226.1 hypothetical protein -
BG597_RS07800 1554479..1554856 - 378 WP_006251227.1 hypothetical protein -
BG597_RS07805 1554859..1555119 - 261 WP_020824317.1 hypothetical protein -
BG597_RS07810 1555131..1556120 - 990 WP_006251229.1 encapsulin -
BG597_RS07815 1556135..1556569 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1532135..1610629 78494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67032 WP_006251221.1 NZ_CP017501:1552214-1552390 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67032 NZ_CP017501:1552214-1552390 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67032 WP_006251222.1 NZ_CP017501:1552446-1552862 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67032 NZ_CP017501:1552446-1552862 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References