Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2394078..2394667 Replicon chromosome
Accession NZ_CP017491
Organism Mannheimia haemolytica strain 38599

Toxin (Protein)


Gene name pemK Uniprot ID A0A248ZY19
Locus tag BG598_RS12260 Protein ID WP_006248516.1
Coordinates 2394335..2394667 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A248ZX26
Locus tag BG598_RS12255 Protein ID WP_006248517.1
Coordinates 2394078..2394338 (+) Length 87 a.a.

Genomic Context

BG598_RS12235BG598_RS12240BG598_RS12245BG598_RS12250BG598_RS12255BG598_RS12260BG598_RS12265BG598_RS12295BG598_RS12300BG598_RS12230BG598_RS12270BG598_RS12275
Location: 2391014..2391658 (645 bp)
Type: Others
Protein ID: WP_006248521.1
Location: 2391660..2392448 (789 bp)
Type: Others
Protein ID: WP_006248520.1
Location: 2392456..2393253 (798 bp)
Type: Others
Protein ID: WP_006248519.1
Location: 2393340..2394008 (669 bp)
Type: Others
Protein ID: WP_006248518.1
Location: 2394078..2394338 (261 bp)
Type: Antitoxin
Protein ID: WP_006248517.1
Location: 2394335..2394667 (333 bp)
Type: Toxin
Protein ID: WP_006248516.1
Location: 2394794..2395825 (1032 bp)
Type: Others
Protein ID: WP_006248514.1
Location: 2397807..2398841 (1035 bp)
Type: Others
Protein ID: WP_006248509.1
Location: 2398852..2399472 (621 bp)
Type: Others
Protein ID: WP_006248508.1
Location: 2389257..2390402 (1146 bp)
Type: Others
Protein ID: WP_006248526.1
Location: 2395889..2396644 (756 bp)
Type: Others
Protein ID: WP_006248513.1
Location: 2396700..2397227 (528 bp)
Type: Others
Protein ID: WP_006248512.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG598_RS122302389257..2390402-1146WP_006248526.1FMN-dependent L-lactate dehydrogenase LldD-
BG598_RS122352391014..2391658+645WP_006248521.1RNA pyrophosphohydrolase-
BG598_RS122402391660..2392448+789WP_006248520.1sulfite exporter TauE/SafE family protein-
BG598_RS122452392456..2393253+798WP_006248519.1prolipoprotein diacylglyceryl transferase-
BG598_RS122502393340..2394008+669WP_006248518.1phosphoglycolate phosphatase-
BG598_RS122552394078..2394338+261WP_006248517.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
BG598_RS122602394335..2394667+333WP_006248516.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BG598_RS122652394794..2395825+1032WP_006248514.1tryptophan--tRNA ligase-
BG598_RS122702395889..2396644-756WP_006248513.1M48 family metallopeptidase-
BG598_RS122752396700..2397227-528WP_006248512.1inorganic diphosphatase-
BG598_RS122952397807..2398841+1035WP_006248509.1endolytic transglycosylase MltG-
BG598_RS123002398852..2399472+621WP_006248508.1dTMP kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12007.94 Da        Isoelectric Point: 6.4597

>T66967 WP_006248516.1 NZ_CP017491:2394335-2394667 [Mannheimia haemolytica]
MKRGDIYWLDLDPTLGHEQSGFRPVVIVSATAFNLASKLPVVVPITNGGAFAERLGFAVSLKDAGLKTTGIIRCDQPRTV
DIAQRHGKFIEALPESLLDEIMARVSVIFE

Download         Length: 333 bp

>T66967 NZ_CP017491:2394335-2394667 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9418.88 Da        Isoelectric Point: 4.7228

>AT66967 WP_006248517.1 NZ_CP017491:2394078-2394338 [Mannheimia haemolytica]
MPTIALRQVGGSVAMVIPPAFLEALKLSVGSKVDLSLNDNQLVINPARPKVKYSLEELLRQSDFEAARNEESQSWLSEPA
IGKEIL

Download         Length: 261 bp

>AT66967 NZ_CP017491:2394078-2394338 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A248ZY19

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZX26

References