Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1818202..1818741 Replicon chromosome
Accession NZ_CP017491
Organism Mannheimia haemolytica strain 38599

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG598_RS09365 Protein ID WP_006247804.1
Coordinates 1818472..1818741 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG598_RS09360 Protein ID WP_006247803.1
Coordinates 1818202..1818468 (+) Length 89 a.a.

Genomic Context

BG598_RS09335BG598_RS09340BG598_RS09345BG598_RS09350BG598_RS09355BG598_RS09360BG598_RS09365BG598_RS09370BG598_RS09375BG598_RS09380BG598_RS09385BG598_RS09390BG598_RS09395BG598_RS09400BG598_RS13715BG598_RS09305BG598_RS09315BG598_RS09320BG598_RS09325BG598_RS09330BG598_RS09405
Location: 1816055..1816282 (228 bp)
Type: Others
Protein ID: Protein_1811
Location: 1816307..1816702 (396 bp)
Type: Others
Protein ID: WP_006247799.1
Location: 1816734..1817375 (642 bp)
Type: Others
Protein ID: WP_006247800.1
Location: 1817458..1817859 (402 bp)
Type: Others
Protein ID: WP_006247801.1
Location: 1817904..1818134 (231 bp)
Type: Others
Protein ID: WP_006247802.1
Location: 1818202..1818468 (267 bp)
Type: Antitoxin
Protein ID: WP_006247803.1
Location: 1818472..1818741 (270 bp)
Type: Toxin
Protein ID: WP_006247804.1
Location: 1818816..1819079 (264 bp)
Type: Others
Protein ID: WP_006247805.1
Location: 1819139..1819849 (711 bp)
Type: Others
Protein ID: WP_006253312.1
Location: 1819827..1820117 (291 bp)
Type: Others
Protein ID: Protein_1820
Location: 1820107..1820826 (720 bp)
Type: Others
Protein ID: WP_006247806.1
Location: 1821048..1821674 (627 bp)
Type: Others
Protein ID: WP_006247807.1
Location: 1821723..1822334 (612 bp)
Type: Others
Protein ID: WP_006253310.1
Location: 1822445..1823131 (687 bp)
Type: Others
Protein ID: WP_006247808.1
Location: 1823141..1823299 (159 bp)
Type: Others
Protein ID: WP_006247809.1
Location: 1813602..1814237 (636 bp)
Type: Others
Protein ID: Protein_1806
Location: 1814338..1815048 (711 bp)
Type: Others
Protein ID: Protein_1807
Location: 1814952..1815275 (324 bp)
Type: Others
Protein ID: WP_006253316.1
Location: 1815356..1815523 (168 bp)
Type: Others
Protein ID: WP_006253314.1
Location: 1815531..1815905 (375 bp)
Type: Others
Protein ID: WP_006247798.1
Location: 1823308..1823607 (300 bp)
Type: Others
Protein ID: WP_006247810.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG598_RS093051813602..1814237-636Protein_1806transposase-
BG598_RS093151814338..1815048-711Protein_1807tyrosine-type recombinase/integrase-
BG598_RS093201814952..1815275-324WP_006253316.1helix-turn-helix domain-containing protein-
BG598_RS093251815356..1815523-168WP_006253314.1DNA cytosine methyltransferase-
BG598_RS093301815531..1815905-375WP_006247798.1hypothetical protein-
BG598_RS093351816055..1816282+228Protein_1811phage terminase large subunit family protein-
BG598_RS093401816307..1816702+396WP_006247799.1phage tail protein-
BG598_RS093451816734..1817375+642WP_006247800.1hypothetical protein-
BG598_RS093501817458..1817859+402WP_006247801.1hypothetical protein-
BG598_RS093551817904..1818134+231WP_006247802.1DUF4035 domain-containing protein-
BG598_RS093601818202..1818468+267WP_006247803.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
BG598_RS093651818472..1818741+270WP_006247804.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
BG598_RS093701818816..1819079+264WP_006247805.1hypothetical protein-
BG598_RS093751819139..1819849+711WP_006253312.1tape measure protein-
BG598_RS093801819827..1820117+291Protein_1820C40 family peptidase-
BG598_RS093851820107..1820826+720WP_006247806.1preprotein translocase subunit YajC-
BG598_RS093901821048..1821674+627WP_006247807.1tail assembly protein-
BG598_RS093951821723..1822334+612WP_006253310.1hypothetical protein-
BG598_RS094001822445..1823131+687WP_006247808.1hypothetical protein-
BG598_RS137151823141..1823299+159WP_006247809.1hypothetical protein-
BG598_RS094051823308..1823607-300WP_006247810.1XRE family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1804295..182608221787
-flankIS/Tn--1813545..1814237692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T66965 WP_006247804.1 NZ_CP017491:1818472-1818741 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T66965 NZ_CP017491:1818472-1818741 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT66965 WP_006247803.1 NZ_CP017491:1818202-1818468 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT66965 NZ_CP017491:1818202-1818468 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A248ZYA9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A547E920

References