Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1818202..1818741 Replicon chromosome
Accession NZ_CP017491
Organism Mannheimia haemolytica strain 38599

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG598_RS09365 Protein ID WP_006247804.1
Coordinates 1818472..1818741 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG598_RS09360 Protein ID WP_006247803.1
Coordinates 1818202..1818468 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG598_RS09305 1813602..1814237 - 636 Protein_1806 transposase -
BG598_RS09315 1814338..1815048 - 711 Protein_1807 tyrosine-type recombinase/integrase -
BG598_RS09320 1814952..1815275 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG598_RS09325 1815356..1815523 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG598_RS09330 1815531..1815905 - 375 WP_006247798.1 hypothetical protein -
BG598_RS09335 1816055..1816282 + 228 Protein_1811 phage terminase large subunit family protein -
BG598_RS09340 1816307..1816702 + 396 WP_006247799.1 phage tail protein -
BG598_RS09345 1816734..1817375 + 642 WP_006247800.1 hypothetical protein -
BG598_RS09350 1817458..1817859 + 402 WP_006247801.1 hypothetical protein -
BG598_RS09355 1817904..1818134 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG598_RS09360 1818202..1818468 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG598_RS09365 1818472..1818741 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG598_RS09370 1818816..1819079 + 264 WP_006247805.1 hypothetical protein -
BG598_RS09375 1819139..1819849 + 711 WP_006253312.1 tape measure protein -
BG598_RS09380 1819827..1820117 + 291 Protein_1820 C40 family peptidase -
BG598_RS09385 1820107..1820826 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG598_RS09390 1821048..1821674 + 627 WP_006247807.1 tail assembly protein -
BG598_RS09395 1821723..1822334 + 612 WP_006253310.1 hypothetical protein -
BG598_RS09400 1822445..1823131 + 687 WP_006247808.1 hypothetical protein -
BG598_RS13715 1823141..1823299 + 159 WP_006247809.1 hypothetical protein -
BG598_RS09405 1823308..1823607 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1804295..1826082 21787
- flank IS/Tn - - 1813545..1814237 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T66965 WP_006247804.1 NZ_CP017491:1818472-1818741 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T66965 NZ_CP017491:1818472-1818741 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT66965 WP_006247803.1 NZ_CP017491:1818202-1818468 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT66965 NZ_CP017491:1818202-1818468 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References