Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1552240..1552888 Replicon chromosome
Accession NZ_CP017491
Organism Mannheimia haemolytica strain 38599

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG598_RS07780 Protein ID WP_006251221.1
Coordinates 1552240..1552416 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG598_RS07785 Protein ID WP_006251222.1
Coordinates 1552472..1552888 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG598_RS07755 1547558..1550053 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG598_RS07765 1550598..1551056 - 459 WP_006251218.1 hypothetical protein -
BG598_RS07770 1551225..1551458 + 234 WP_020824316.1 hypothetical protein -
BG598_RS07775 1551473..1552144 - 672 WP_006251220.1 hypothetical protein -
BG598_RS07780 1552240..1552416 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG598_RS07785 1552472..1552888 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG598_RS07790 1552928..1553410 - 483 WP_006251223.1 phage tail protein -
BG598_RS07795 1553414..1553794 - 381 WP_006251224.1 hypothetical protein -
BG598_RS07800 1553791..1554159 - 369 WP_006251225.1 hypothetical protein -
BG598_RS07805 1554161..1554505 - 345 WP_006251226.1 hypothetical protein -
BG598_RS07810 1554505..1554882 - 378 WP_006251227.1 hypothetical protein -
BG598_RS13670 1554885..1555154 - 270 WP_020849873.1 hypothetical protein -
BG598_RS07820 1555166..1556155 - 990 WP_006251229.1 encapsulin -
BG598_RS07825 1556170..1556604 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1532161..1610664 78503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T66963 WP_006251221.1 NZ_CP017491:1552240-1552416 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T66963 NZ_CP017491:1552240-1552416 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT66963 WP_006251222.1 NZ_CP017491:1552472-1552888 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT66963 NZ_CP017491:1552472-1552888 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References