Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 527327..527977 Replicon chromosome
Accession NZ_CP017491
Organism Mannheimia haemolytica strain 38599

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag BG598_RS02625 Protein ID WP_006249411.1
Coordinates 527588..527977 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag BG598_RS02620 Protein ID WP_006249412.1
Coordinates 527327..527587 (+) Length 87 a.a.

Genomic Context

BG598_RS02605BG598_RS02610BG598_RS02615BG598_RS02620BG598_RS02625BG598_RS02630BG598_RS02670BG598_RS02675BG598_RS02680
Location: 523015..526548 (3534 bp)
Type: Others
Protein ID: WP_006253629.1
Location: 526711..526998 (288 bp)
Type: Others
Protein ID: WP_006251764.1
Location: 526999..527211 (213 bp)
Type: Others
Protein ID: WP_006251765.1
Location: 527327..527587 (261 bp)
Type: Antitoxin
Protein ID: WP_006249412.1
Location: 527588..527977 (390 bp)
Type: Toxin
Protein ID: WP_006249411.1
Location: 527997..529235 (1239 bp)
Type: Others
Protein ID: WP_006253630.1
Location: 530185..530970 (786 bp)
Type: Others
Protein ID: WP_006251768.1
Location: 531044..531904 (861 bp)
Type: Others
Protein ID: WP_006250124.1
Location: 531897..532706 (810 bp)
Type: Others
Protein ID: WP_006250123.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG598_RS02605523015..526548+3534WP_006253629.1transcription-repair coupling factor-
BG598_RS02610526711..526998+288WP_006251764.1BrnT family toxin-
BG598_RS02615526999..527211+213WP_006251765.1BrnA antitoxin family protein-
BG598_RS02620527327..527587+261WP_006249412.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
BG598_RS02625527588..527977+390WP_006249411.1type II toxin-antitoxin system VapC family toxinToxin
BG598_RS02630527997..529235+1239WP_006253630.1peptidase T-
BG598_RS02670530185..530970+786WP_006251768.1hypothetical protein-
BG598_RS02675531044..531904+861WP_006250124.1metal ABC transporter permease-
BG598_RS02680531897..532706+810WP_006250123.1metal ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T66961 WP_006249411.1 NZ_CP017491:527588-527977 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T66961 NZ_CP017491:527588-527977 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT66961 WP_006249412.1 NZ_CP017491:527327-527587 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp

>AT66961 NZ_CP017491:527327-527587 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A547EDJ6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A547EDM1

References