Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2298311..2298959 Replicon chromosome
Accession NZ_CP017489
Organism Mannheimia haemolytica strain 39309

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG570_RS11600 Protein ID WP_006251221.1
Coordinates 2298311..2298487 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG570_RS11605 Protein ID WP_006251222.1
Coordinates 2298543..2298959 (+) Length 139 a.a.

Genomic Context

BG570_RS11590BG570_RS11600BG570_RS11605BG570_RS11575BG570_RS11580BG570_RS11585BG570_RS11595BG570_RS11610BG570_RS11615BG570_RS11620BG570_RS11625BG570_RS11630BG570_RS13410BG570_RS11635BG570_RS11640
Location: 2297295..2297528 (234 bp)
Type: Others
Protein ID: WP_020824316.1
Location: 2298311..2298487 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Location: 2298543..2298959 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 2293623..2296118 (2496 bp)
Type: Others
Protein ID: WP_061888644.1
Location: 2296205..2296600 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Location: 2296668..2297126 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Location: 2297543..2298214 (672 bp)
Type: Others
Protein ID: WP_006251220.1
Location: 2298999..2299481 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Location: 2299485..2299865 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Location: 2299862..2300230 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Location: 2300232..2300576 (345 bp)
Type: Others
Protein ID: WP_006251226.1
Location: 2300576..2300953 (378 bp)
Type: Others
Protein ID: WP_006251227.1
Location: 2300956..2301261 (306 bp)
Type: Others
Protein ID: WP_015587049.1
Location: 2301273..2302259 (987 bp)
Type: Others
Protein ID: WP_062627922.1
Location: 2302274..2302708 (435 bp)
Type: Others
Protein ID: WP_006251230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG570_RS115752293623..2296118-2496WP_061888644.1phage tail length tape measure family protein-
BG570_RS115802296205..2296600-396WP_006251217.1hypothetical protein-
BG570_RS115852296668..2297126-459WP_006251218.1hypothetical protein-
BG570_RS115902297295..2297528+234WP_020824316.1hypothetical protein-
BG570_RS115952297543..2298214-672WP_006251220.1hypothetical protein-
BG570_RS116002298311..2298487+177WP_006251221.1type II toxin-antitoxin system HicA family toxinToxin
BG570_RS116052298543..2298959+417WP_006251222.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BG570_RS116102298999..2299481-483WP_006251223.1phage tail protein-
BG570_RS116152299485..2299865-381WP_006251224.1hypothetical protein-
BG570_RS116202299862..2300230-369WP_006251225.1hypothetical protein-
BG570_RS116252300232..2300576-345WP_006251226.1hypothetical protein-
BG570_RS116302300576..2300953-378WP_006251227.1hypothetical protein-
BG570_RS134102300956..2301261-306WP_015587049.1hypothetical protein-
BG570_RS116352301273..2302259-987WP_062627922.1encapsulin-
BG570_RS116402302274..2302708-435WP_006251230.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2284637..233632451687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T66951 WP_006251221.1 NZ_CP017489:2298311-2298487 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T66951 NZ_CP017489:2298311-2298487 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT66951 WP_006251222.1 NZ_CP017489:2298543-2298959 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT66951 NZ_CP017489:2298543-2298959 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A249A099

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZZL6

References