Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2144402..2144924 Replicon chromosome
Accession NZ_CP017489
Organism Mannheimia haemolytica strain 39309

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZX63
Locus tag BG570_RS10750 Protein ID WP_006250322.1
Coordinates 2144402..2144671 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag BG570_RS10755 Protein ID WP_006250323.1
Coordinates 2144658..2144924 (-) Length 89 a.a.

Genomic Context

BG570_RS10745BG570_RS10760BG570_RS10765BG570_RS10770BG570_RS10780BG570_RS10730BG570_RS10735BG570_RS10740BG570_RS10750BG570_RS10755
Location: 2142500..2144383 (1884 bp)
Type: Others
Protein ID: WP_006251983.1
Location: 2145370..2146323 (954 bp)
Type: Others
Protein ID: WP_006251982.1
Location: 2146392..2146664 (273 bp)
Type: Others
Protein ID: WP_006250326.1
Location: 2146684..2148069 (1386 bp)
Type: Others
Protein ID: WP_020824252.1
Location: 2148406..2149446 (1041 bp)
Type: Others
Protein ID: WP_020824044.1
Location: 2139722..2140156 (435 bp)
Type: Others
Protein ID: WP_006250318.1
Location: 2140131..2140976 (846 bp)
Type: Others
Protein ID: WP_006251985.1
Location: 2140978..2142216 (1239 bp)
Type: Others
Protein ID: WP_006251984.1
Location: 2144402..2144671 (270 bp)
Type: Toxin
Protein ID: WP_006250322.1
Location: 2144658..2144924 (267 bp)
Type: Antitoxin
Protein ID: WP_006250323.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG570_RS107302139722..2140156-435WP_006250318.1D-tyrosyl-tRNA(Tyr) deacylase-
BG570_RS107352140131..2140976-846WP_006251985.1virulence factor BrkB family protein-
BG570_RS107402140978..2142216-1239WP_006251984.1glutamate-5-semialdehyde dehydrogenase-
BG570_RS107452142500..2144383+1884WP_006251983.1DNA mismatch repair endonuclease MutL-
BG570_RS107502144402..2144671-270WP_006250322.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
BG570_RS107552144658..2144924-267WP_006250323.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
BG570_RS107602145370..2146323+954WP_006251982.1tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA-
BG570_RS107652146392..2146664+273WP_006250326.1RNA chaperone Hfq-
BG570_RS107702146684..2148069+1386WP_020824252.1GTPase HflX-
BG570_RS107802148406..2149446+1041WP_020824044.1IS481 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2148406..21494461040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 6.4732

>T66950 WP_006250322.1 NZ_CP017489:c2144671-2144402 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

>T66950 NZ_CP017489:c2144671-2144402 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GTTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT66950 WP_006250323.1 NZ_CP017489:c2144924-2144658 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp

>AT66950 NZ_CP017489:c2144924-2144658 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A248ZX63

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZY54

References