Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1957638..1958278 Replicon chromosome
Accession NZ_CP017489
Organism Mannheimia haemolytica strain 39309

Toxin (Protein)


Gene name hicA Uniprot ID A0A378NFX7
Locus tag BG570_RS09725 Protein ID WP_006250075.1
Coordinates 1957638..1957820 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A378NET2
Locus tag BG570_RS09730 Protein ID WP_006250984.1
Coordinates 1957859..1958278 (+) Length 140 a.a.

Genomic Context

BG570_RS09710BG570_RS09715BG570_RS09720BG570_RS09725BG570_RS09730BG570_RS09745BG570_RS09755BG570_RS13380BG570_RS09760BG570_RS09765BG570_RS09770BG570_RS09775BG570_RS09690BG570_RS09695BG570_RS09700BG570_RS09705BG570_RS09735BG570_RS09740BG570_RS09750
Location: 1955879..1956562 (684 bp)
Type: Others
Protein ID: WP_006252485.1
Location: 1956637..1957017 (381 bp)
Type: Others
Protein ID: WP_006248823.1
Location: 1957022..1957507 (486 bp)
Type: Others
Protein ID: WP_006252741.1
Location: 1957638..1957820 (183 bp)
Type: Toxin
Protein ID: WP_006250075.1
Location: 1957859..1958278 (420 bp)
Type: Antitoxin
Protein ID: WP_006250984.1
Location: 1959224..1959454 (231 bp)
Type: Others
Protein ID: WP_006250987.1
Location: 1960449..1960634 (186 bp)
Type: Others
Protein ID: WP_020824222.1
Location: 1960618..1960782 (165 bp)
Type: Others
Protein ID: WP_020824223.1
Location: 1960788..1961246 (459 bp)
Type: Others
Protein ID: WP_006253113.1
Location: 1961282..1961641 (360 bp)
Type: Others
Protein ID: WP_006250991.1
Location: 1961713..1962516 (804 bp)
Type: Others
Protein ID: WP_020824224.1
Location: 1962568..1963002 (435 bp)
Type: Others
Protein ID: WP_020824225.1
Location: 1953209..1954255 (1047 bp)
Type: Others
Protein ID: WP_020824125.1
Location: 1954252..1955091 (840 bp)
Type: Others
Protein ID: WP_006252350.1
Location: 1955267..1955527 (261 bp)
Type: Others
Protein ID: WP_006252483.1
Location: 1955548..1955748 (201 bp)
Type: Others
Protein ID: WP_006248825.1
Location: 1958345..1958650 (306 bp)
Type: Others
Protein ID: WP_006250985.1
Location: 1958659..1958934 (276 bp)
Type: Others
Protein ID: WP_006250986.1
Location: 1959933..1960256 (324 bp)
Type: Others
Protein ID: WP_006250988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG570_RS096901953209..1954255-1047WP_020824125.1conserved phage C-terminal domain-containing protein-
BG570_RS096951954252..1955091-840WP_006252350.1Rha family transcriptional regulator-
BG570_RS097001955267..1955527-261WP_006252483.1hypothetical protein-
BG570_RS097051955548..1955748-201WP_006248825.1helix-turn-helix domain-containing protein-
BG570_RS097101955879..1956562+684WP_006252485.1helix-turn-helix transcriptional regulator-
BG570_RS097151956637..1957017+381WP_006248823.1hypothetical protein-
BG570_RS097201957022..1957507+486WP_006252741.1hypothetical protein-
BG570_RS097251957638..1957820+183WP_006250075.1type II toxin-antitoxin system HicA family toxinToxin
BG570_RS097301957859..1958278+420WP_006250984.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BG570_RS097351958345..1958650-306WP_006250985.1HigA family addiction module antidote protein-
BG570_RS097401958659..1958934-276WP_006250986.1type II toxin-antitoxin system RelE/ParE family toxin-
BG570_RS097451959224..1959454+231WP_006250987.1hypothetical protein-
BG570_RS097501959933..1960256-324WP_006250988.1hypothetical protein-
BG570_RS097551960449..1960634+186WP_020824222.1hypothetical protein-
BG570_RS133801960618..1960782+165WP_020824223.1hypothetical protein-
BG570_RS097601960788..1961246+459WP_006253113.1single-stranded DNA-binding protein-
BG570_RS097651961282..1961641+360WP_006250991.1hypothetical protein-
BG570_RS097701961713..1962516+804WP_020824224.1DUF2303 family protein-
BG570_RS097751962568..1963002+435WP_020824225.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1921282..196808746805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-96)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.03 Da        Isoelectric Point: 10.3446

>T66949 WP_006250075.1 NZ_CP017489:1957638-1957820 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK

Download         Length: 183 bp

>T66949 NZ_CP017489:1957638-1957820 [Mannheimia haemolytica]
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15957.34 Da        Isoelectric Point: 4.6983

>AT66949 WP_006250984.1 NZ_CP017489:1957859-1958278 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH

Download         Length: 420 bp

>AT66949 NZ_CP017489:1957859-1958278 [Mannheimia haemolytica]
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATACCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGTAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACGCT
TTACTATTCTCCCTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A378NFX7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A378NET2

References