Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 491053..491703 Replicon chromosome
Accession NZ_CP017489
Organism Mannheimia haemolytica strain 39309

Toxin (Protein)


Gene name vapC Uniprot ID A0A378NBZ4
Locus tag BG570_RS02435 Protein ID WP_020831127.1
Coordinates 491314..491703 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag BG570_RS02430 Protein ID WP_006251766.1
Coordinates 491053..491313 (+) Length 87 a.a.

Genomic Context

BG570_RS02415BG570_RS02420BG570_RS02425BG570_RS02430BG570_RS02435BG570_RS02440BG570_RS02480BG570_RS02485BG570_RS02490
Location: 486741..490274 (3534 bp)
Type: Others
Protein ID: WP_006251763.1
Location: 490437..490724 (288 bp)
Type: Others
Protein ID: WP_020831126.1
Location: 490725..490937 (213 bp)
Type: Others
Protein ID: WP_006251765.1
Location: 491053..491313 (261 bp)
Type: Antitoxin
Protein ID: WP_006251766.1
Location: 491314..491703 (390 bp)
Type: Toxin
Protein ID: WP_020831127.1
Location: 491723..492961 (1239 bp)
Type: Others
Protein ID: WP_006251767.1
Location: 493951..494736 (786 bp)
Type: Others
Protein ID: WP_006251768.1
Location: 494810..495670 (861 bp)
Type: Others
Protein ID: WP_006250124.1
Location: 495663..496472 (810 bp)
Type: Others
Protein ID: WP_006250123.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG570_RS02415486741..490274+3534WP_006251763.1transcription-repair coupling factor-
BG570_RS02420490437..490724+288WP_020831126.1BrnT family toxin-
BG570_RS02425490725..490937+213WP_006251765.1BrnA antitoxin family protein-
BG570_RS02430491053..491313+261WP_006251766.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
BG570_RS02435491314..491703+390WP_020831127.1type II toxin-antitoxin system VapC family toxinToxin
BG570_RS02440491723..492961+1239WP_006251767.1peptidase T-
BG570_RS02480493951..494736+786WP_006251768.1hypothetical protein-
BG570_RS02485494810..495670+861WP_006250124.1metal ABC transporter permease-
BG570_RS02490495663..496472+810WP_006250123.1metal ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14575.87 Da        Isoelectric Point: 7.7391

>T66946 WP_020831127.1 NZ_CP017489:491314-491703 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T66946 NZ_CP017489:491314-491703 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGGTTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGCGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT66946 WP_006251766.1 NZ_CP017489:491053-491313 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp

>AT66946 NZ_CP017489:491053-491313 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAACAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A378NBZ4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1D2Q6P1

References