Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2299072..2299720 Replicon chromosome
Accession NZ_CP017486
Organism Mannheimia haemolytica strain 39394

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG552_RS11580 Protein ID WP_006251221.1
Coordinates 2299072..2299248 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG552_RS11585 Protein ID WP_006251222.1
Coordinates 2299304..2299720 (+) Length 139 a.a.

Genomic Context

BG552_RS11570BG552_RS11580BG552_RS11585BG552_RS11555BG552_RS11560BG552_RS11565BG552_RS11575BG552_RS11590BG552_RS11595BG552_RS11600BG552_RS11605BG552_RS11610BG552_RS13365BG552_RS11620BG552_RS11625
Location: 2298020..2298289 (270 bp)
Type: Others
Protein ID: WP_006251219.1
Location: 2299072..2299248 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Location: 2299304..2299720 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 2294384..2296879 (2496 bp)
Type: Others
Protein ID: WP_061888644.1
Location: 2296966..2297361 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Location: 2297429..2297887 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Location: 2298304..2298975 (672 bp)
Type: Others
Protein ID: WP_006251220.1
Location: 2299760..2300242 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Location: 2300246..2300626 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Location: 2300623..2300991 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Location: 2300993..2301337 (345 bp)
Type: Others
Protein ID: WP_006251226.1
Location: 2301337..2301714 (378 bp)
Type: Others
Protein ID: WP_006251227.1
Location: 2301717..2301986 (270 bp)
Type: Others
Protein ID: WP_020849873.1
Location: 2301998..2302984 (987 bp)
Type: Others
Protein ID: WP_062627922.1
Location: 2302999..2303433 (435 bp)
Type: Others
Protein ID: WP_006251230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG552_RS115552294384..2296879-2496WP_061888644.1phage tail length tape measure family protein-
BG552_RS115602296966..2297361-396WP_006251217.1hypothetical protein-
BG552_RS115652297429..2297887-459WP_006251218.1hypothetical protein-
BG552_RS115702298020..2298289+270WP_006251219.1hypothetical protein-
BG552_RS115752298304..2298975-672WP_006251220.1hypothetical protein-
BG552_RS115802299072..2299248+177WP_006251221.1type II toxin-antitoxin system HicA family toxinToxin
BG552_RS115852299304..2299720+417WP_006251222.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BG552_RS115902299760..2300242-483WP_006251223.1phage tail protein-
BG552_RS115952300246..2300626-381WP_006251224.1hypothetical protein-
BG552_RS116002300623..2300991-369WP_006251225.1hypothetical protein-
BG552_RS116052300993..2301337-345WP_006251226.1hypothetical protein-
BG552_RS116102301337..2301714-378WP_006251227.1hypothetical protein-
BG552_RS133652301717..2301986-270WP_020849873.1hypothetical protein-
BG552_RS116202301998..2302984-987WP_062627922.1encapsulin-
BG552_RS116252302999..2303433-435WP_006251230.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2285398..233704951651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T66929 WP_006251221.1 NZ_CP017486:2299072-2299248 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T66929 NZ_CP017486:2299072-2299248 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT66929 WP_006251222.1 NZ_CP017486:2299304-2299720 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT66929 NZ_CP017486:2299304-2299720 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A249A099

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZZL6

References