Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 803025..803547 Replicon chromosome
Accession NZ_CP017486
Organism Mannheimia haemolytica strain 39394

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag BG552_RS04055 Protein ID WP_006249269.1
Coordinates 803025..803321 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A378NDF7
Locus tag BG552_RS04060 Protein ID WP_006250574.1
Coordinates 803305..803547 (+) Length 81 a.a.

Genomic Context

BG552_RS04040BG552_RS04045BG552_RS04050BG552_RS04055BG552_RS04060BG552_RS04065BG552_RS04075BG552_RS04080BG552_RS04085BG552_RS04070
Location: 798080..799405 (1326 bp)
Type: Others
Protein ID: WP_020831251.1
Location: 799526..799825 (300 bp)
Type: Others
Protein ID: WP_006249265.1
Location: 799986..802898 (2913 bp)
Type: Others
Protein ID: WP_006250573.1
Location: 803025..803321 (297 bp)
Type: Toxin
Protein ID: WP_006249269.1
Location: 803305..803547 (243 bp)
Type: Antitoxin
Protein ID: WP_006250574.1
Location: 803559..804227 (669 bp)
Type: Others
Protein ID: WP_006249271.1
Location: 804840..805682 (843 bp)
Type: Others
Protein ID: WP_006250575.1
Location: 805805..806446 (642 bp)
Type: Others
Protein ID: WP_006250576.1
Location: 806620..807697 (1078 bp)
Type: Others
Protein ID: Protein_782
Location: 804205..804780 (576 bp)
Type: Others
Protein ID: WP_006249272.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG552_RS04040798080..799405+1326WP_020831251.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
BG552_RS04045799526..799825+300WP_006249265.1hypothetical protein-
BG552_RS04050799986..802898+2913WP_006250573.1RNA polymerase-associated protein RapA-
BG552_RS04055803025..803321+297WP_006249269.1BrnT family toxinToxin
BG552_RS04060803305..803547+243WP_006250574.1hypothetical proteinAntitoxin
BG552_RS04065803559..804227+669WP_006249271.1bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA-
BG552_RS04070804205..804780-576WP_006249272.11,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD-
BG552_RS04075804840..805682+843WP_006250575.123S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ-
BG552_RS04080805805..806446+642WP_006250576.1orotate phosphoribosyltransferase-
BG552_RS04085806620..807697+1078Protein_7825-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T66926 WP_006249269.1 NZ_CP017486:803025-803321 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

>T66926 NZ_CP017486:803025-803321 [Mannheimia haemolytica]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9320.71 Da        Isoelectric Point: 7.1665

>AT66926 WP_006250574.1 NZ_CP017486:803305-803547 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALSKMWIAEKLPVQSPR

Download         Length: 243 bp

>AT66926 NZ_CP017486:803305-803547 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGAGTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A249A107

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A378NDF7

References