Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2298317..2298965 Replicon chromosome
Accession NZ_CP017485
Organism Mannheimia haemolytica strain 39409

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG571_RS11610 Protein ID WP_006251221.1
Coordinates 2298317..2298493 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG571_RS11615 Protein ID WP_006251222.1
Coordinates 2298549..2298965 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG571_RS11585 2293629..2296124 - 2496 WP_061888644.1 phage tail length tape measure family protein -
BG571_RS11590 2296211..2296606 - 396 WP_006251217.1 hypothetical protein -
BG571_RS11595 2296674..2297132 - 459 WP_006251218.1 hypothetical protein -
BG571_RS11600 2297265..2297534 + 270 WP_006251219.1 hypothetical protein -
BG571_RS11605 2297549..2298220 - 672 WP_006251220.1 hypothetical protein -
BG571_RS11610 2298317..2298493 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG571_RS11615 2298549..2298965 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG571_RS11620 2299005..2299487 - 483 WP_006251223.1 phage tail protein -
BG571_RS11625 2299491..2299871 - 381 WP_006251224.1 hypothetical protein -
BG571_RS11630 2299868..2300236 - 369 WP_006251225.1 hypothetical protein -
BG571_RS11635 2300238..2300582 - 345 WP_006251226.1 hypothetical protein -
BG571_RS11640 2300582..2300959 - 378 WP_006251227.1 hypothetical protein -
BG571_RS13390 2300962..2301267 - 306 WP_015587049.1 hypothetical protein -
BG571_RS11645 2301279..2302265 - 987 WP_062627922.1 encapsulin -
BG571_RS11650 2302280..2302714 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2284643..2336330 51687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T66922 WP_006251221.1 NZ_CP017485:2298317-2298493 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T66922 NZ_CP017485:2298317-2298493 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT66922 WP_006251222.1 NZ_CP017485:2298549-2298965 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT66922 NZ_CP017485:2298549-2298965 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References