Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2570694..2571409 Replicon chromosome
Accession NZ_CP017484
Organism Mannheimia haemolytica strain 39433

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BG572_RS13150 Protein ID WP_006250491.1
Coordinates 2570981..2571409 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag BG572_RS13145 Protein ID WP_006248272.1
Coordinates 2570694..2570981 (+) Length 96 a.a.

Genomic Context

BG572_RS13145BG572_RS13150BG572_RS13155BG572_RS13125BG572_RS13130BG572_RS13135BG572_RS13140BG572_RS13160BG572_RS13165
Location: 2570694..2570981 (288 bp)
Type: Antitoxin
Protein ID: WP_006248272.1
Location: 2570981..2571409 (429 bp)
Type: Toxin
Protein ID: WP_006250491.1
Location: 2571413..2573494 (2082 bp)
Type: Others
Protein ID: WP_006250490.1
Location: 2566369..2566425 (57 bp)
Type: Others
Protein ID: WP_075271894.1
Location: 2566533..2568248 (1716 bp)
Type: Others
Protein ID: WP_006248268.1
Location: 2568412..2568594 (183 bp)
Type: Others
Protein ID: WP_006250493.1
Location: 2568647..2570530 (1884 bp)
Type: Others
Protein ID: WP_006250492.1
Location: 2573516..2574448 (933 bp)
Type: Others
Protein ID: WP_006250489.1
Location: 2574501..2576153 (1653 bp)
Type: Others
Protein ID: WP_006250488.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG572_RS131252566369..2566425-57WP_075271894.1PT domain-containing protein-
BG572_RS131302566533..2568248-1716WP_006248268.1proline--tRNA ligase-
BG572_RS131352568412..2568594-183WP_006250493.1hypothetical protein-
BG572_RS131402568647..2570530-1884WP_006250492.1molecular chaperone HtpG-
BG572_RS131452570694..2570981+288WP_006248272.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
BG572_RS131502570981..2571409+429WP_006250491.1type II toxin-antitoxin system VapC family toxinToxin
BG572_RS131552571413..2573494+2082WP_006250490.1ATP-dependent DNA helicase RecG-
BG572_RS131602573516..2574448-933WP_006250489.1nucleoside hydrolase-
BG572_RS131652574501..2576153-1653WP_006250488.1phospho-sugar mutase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T66916 WP_006250491.1 NZ_CP017484:2570981-2571409 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T66916 NZ_CP017484:2570981-2571409 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT66916 WP_006248272.1 NZ_CP017484:2570694-2570981 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp

>AT66916 NZ_CP017484:2570694-2570981 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZW87

References