Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4005972..4007626 Replicon chromosome
Accession NZ_CP017483
Organism Stenotrophomonas sp. LM091

Toxin (Protein)


Gene name HipA3 Uniprot ID A0A1D8YEE0
Locus tag BIZ42_RS17825 Protein ID WP_070427230.1
Coordinates 4005972..4007279 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID A0A1D8YE93
Locus tag BIZ42_RS17830 Protein ID WP_070427231.1
Coordinates 4007276..4007626 (-) Length 117 a.a.

Genomic Context

BIZ42_RS17815BIZ42_RS17835BIZ42_RS17820BIZ42_RS17825BIZ42_RS17830BIZ42_RS17840BIZ42_RS17845BIZ42_RS17850
Location: 4002069..4002704 (636 bp)
Type: Others
Protein ID: WP_070427228.1
Location: 4007957..4009123 (1167 bp)
Type: Others
Protein ID: WP_070427232.1
Location: 4002717..4005836 (3120 bp)
Type: Others
Protein ID: WP_070427229.1
Location: 4005972..4007279 (1308 bp)
Type: Toxin
Protein ID: WP_070427230.1
Location: 4007276..4007626 (351 bp)
Type: Antitoxin
Protein ID: WP_070427231.1
Location: 4009134..4010003 (870 bp)
Type: Others
Protein ID: WP_046273775.1
Location: 4010054..4011103 (1050 bp)
Type: Others
Protein ID: WP_019183057.1
Location: 4011100..4012155 (1056 bp)
Type: Others
Protein ID: WP_070427233.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BIZ42_RS178154002069..4002704+636WP_070427228.1cupin domain-containing protein-
BIZ42_RS178204002717..4005836-3120WP_070427229.1discoidin domain-containing protein-
BIZ42_RS178254005972..4007279-1308WP_070427230.1type II toxin-antitoxin system HipA family toxinToxin
BIZ42_RS178304007276..4007626-351WP_070427231.1helix-turn-helix transcriptional regulatorAntitoxin
BIZ42_RS178354007957..4009123+1167WP_070427232.1nucleotide sugar dehydrogenase-
BIZ42_RS178404009134..4010003-870WP_046273775.1DMT family transporter-
BIZ42_RS178454010054..4011103-1050WP_019183057.1UDP-N-acetylmuramate dehydrogenase-
BIZ42_RS178504011100..4012155-1056WP_070427233.1quinone-dependent dihydroorotate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-117)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48305.44 Da        Isoelectric Point: 6.6655

>T66908 WP_070427230.1 NZ_CP017483:c4007279-4005972 [Stenotrophomonas sp. LM091]
MSTTAEVRLWGSRIGAVTLADGERVAQFAYDPAFARSSIEVAPLTMPLAAERVFSFPSLNPAGFHGLPGLLADALPDKYG
NTLINAWLATQGRTPDSFNAVERLCYTGTRGMGALEFSPVHGPRVRTAHKIQIDALVALATEVLSNRDNLRASFGDEERA
DALRDILRVGTSAGGARAKAVIAWNESTGEVRSGQAAAAPGFSYWLLKFDGVQNNRDKELADPKGYGVVEYAYALMARDA
GIQISECRLLEEGGRRHFMTQRFDRTEAGGKHHMQSLAAMAHFDFNDPDAYSYEQALLVMRQLRLPMAQLEEQFRRMVFN
VIARNQDDHVKNIAYLMDRQGQWSLSPAFDITWAYNPDGDWTARHQMSINGKREGFDVADLAACAATASINARRARDIIE
QVRQSVLRWPHFADEAGVAEIWRDQIRGSLRTDIR

Download         Length: 1308 bp

>T66908 NZ_CP017483:c4007279-4005972 [Stenotrophomonas sp. LM091]
ATGAGTACCACGGCCGAGGTGCGCTTGTGGGGCAGCCGGATCGGCGCGGTGACACTGGCCGACGGCGAGCGGGTCGCGCA
GTTTGCCTACGACCCGGCGTTTGCACGCTCCAGCATCGAAGTCGCCCCTCTGACCATGCCGTTGGCGGCGGAGCGGGTCT
TCAGCTTCCCCTCGCTCAACCCCGCGGGCTTCCATGGCCTGCCCGGCCTGCTCGCCGATGCCCTGCCGGACAAGTACGGC
AACACCCTGATCAACGCGTGGCTGGCCACGCAGGGCCGCACCCCGGACAGCTTCAACGCGGTGGAGCGGCTGTGCTACAC
CGGCACGCGCGGCATGGGCGCGCTGGAGTTCTCGCCCGTGCATGGTCCGCGCGTGCGCACGGCGCACAAGATCCAGATCG
ATGCCCTGGTCGCGCTGGCCACCGAAGTCCTGAGCAACCGCGACAATCTGCGTGCCTCCTTCGGTGATGAAGAACGCGCC
GATGCGCTGCGCGACATTCTGCGCGTGGGCACCTCGGCCGGTGGCGCACGGGCCAAAGCCGTGATCGCCTGGAACGAAAG
CACCGGTGAGGTCCGATCGGGCCAGGCCGCGGCCGCGCCAGGCTTCAGCTACTGGCTGCTCAAGTTCGATGGCGTACAGA
ACAACCGCGACAAGGAGCTGGCTGACCCCAAAGGTTACGGCGTGGTCGAGTACGCGTACGCGCTGATGGCACGGGATGCG
GGCATCCAGATCAGCGAGTGCCGGCTGCTGGAGGAAGGCGGCCGCCGCCACTTCATGACCCAACGCTTCGACCGCACCGA
GGCCGGTGGCAAGCACCATATGCAGTCGCTGGCGGCAATGGCCCACTTCGACTTCAACGATCCCGATGCGTACTCCTATG
AGCAGGCGTTGCTGGTCATGCGCCAGCTGCGCCTGCCCATGGCGCAGCTGGAAGAACAGTTCCGGCGGATGGTGTTCAAC
GTGATCGCGCGCAACCAGGACGACCACGTCAAGAACATCGCCTACCTGATGGACCGGCAGGGCCAATGGTCGCTGTCCCC
GGCGTTCGACATCACCTGGGCGTACAACCCGGACGGCGACTGGACGGCCCGGCACCAGATGTCGATCAACGGCAAGCGCG
AGGGGTTCGACGTGGCCGACCTGGCCGCATGCGCCGCCACCGCCTCGATCAATGCCCGCCGCGCCCGGGACATCATTGAG
CAGGTCCGGCAAAGCGTGCTGCGCTGGCCACACTTTGCCGACGAGGCCGGCGTCGCCGAGATCTGGCGCGATCAGATCCG
CGGCAGCCTGCGCACGGACATTCGCTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12805.68 Da        Isoelectric Point: 8.7364

>AT66908 WP_070427231.1 NZ_CP017483:c4007626-4007276 [Stenotrophomonas sp. LM091]
MTITHLMTDEAVLLELGLRLARMRLSQGLTQEQLADAAGVSKRTVQRLEDGTPAQLANLIRYLRALGRLEALDALLPSDS
PNPIDLLERRGQPRQRARPGVAASTPAKPWTWGDEQ

Download         Length: 351 bp

>AT66908 NZ_CP017483:c4007626-4007276 [Stenotrophomonas sp. LM091]
ATGACAATCACACATCTGATGACCGACGAGGCGGTGCTGCTGGAGCTCGGGCTACGCCTTGCGCGCATGCGCCTTTCGCA
GGGACTCACCCAGGAACAGCTGGCGGATGCGGCCGGCGTCTCCAAGCGCACCGTGCAGCGGCTCGAAGACGGTACGCCCG
CGCAACTGGCCAACCTGATCCGGTACCTGCGCGCCCTCGGCAGGCTGGAGGCGCTGGACGCCCTGCTGCCCAGCGACAGC
CCCAATCCGATCGACCTGCTGGAACGCCGCGGCCAGCCGCGCCAGCGTGCCCGACCGGGGGTGGCCGCGTCGACCCCGGC
CAAGCCGTGGACGTGGGGCGATGAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1D8YEE0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1D8YE93

References