Detailed information of TA system TA066904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4271859..4272384
• Replicon: chromosome
• Accession: NZ_CP017482
• Organism: Pectobacterium polaris strain NIBIO1392

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BJK05_RS19445
• Protein ID: WP_095701405.1
• Coordinates: 4272100..4272384 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: BJK05_RS19440
• Protein ID: WP_005973616.1
• Coordinates: 4271859..4272110 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJK05_RS19405	4267457..4267717	+	261	WP_039539552.1	AlpA family transcriptional regulator	-
BJK05_RS19410	4267714..4267938	+	225	WP_095701401.1	hypothetical protein	-
BJK05_RS22855	4267947..4268273	+	327	Protein_3725	ash family protein	-
BJK05_RS22860	4268294..4268491	+	198	WP_125460691.1	host cell division inhibitor Icd-like protein	-
BJK05_RS19420	4268484..4268678	+	195	WP_005973630.1	hypothetical protein	-
BJK05_RS19425	4268675..4268941	+	267	WP_095701402.1	hypothetical protein	-
BJK05_RS19430	4268938..4269279	+	342	WP_095701403.1	DUF5375 family protein	-
BJK05_RS19435	4269290..4271617	+	2328	WP_095701404.1	toprim domain-containing protein	-
BJK05_RS19440	4271859..4272110	+	252	WP_005973616.1	prevent-host-death protein	Antitoxin
BJK05_RS19445	4272100..4272384	+	285	WP_095701405.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJK05_RS19450	4272900..4274142	+	1243	Protein_3733	integrase arm-type DNA-binding domain-containing protein	-
BJK05_RS19455	4274174..4275847	-	1674	WP_095701406.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4261365..4275847	14482

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.02 Da
• Isoelectric Point: 10.1716

>T66904 WP_095701405.1 NZ_CP017482:4272100-4272384 [Pectobacterium polaris]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAMGK
RERSEVYKTAKDRL

Nucleotide

• Length: 285 bp

>T66904 NZ_CP017482:4272100-4272384 [Pectobacterium polaris]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCGCCCGTGCGGGAGCAGTTCAC
CAAAAAACTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCCGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTACCAAGTACTTGAGCATGAGATCGTGGTGCTGGTTTTAGCTATGGGCAAA
CGGGAACGCTCAGAAGTTTATAAAACAGCGAAAGACCGACTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT66904 WP_005973616.1 NZ_CP017482:4271859-4272110 [Pectobacterium polaris]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT66904 NZ_CP017482:4271859-4272110 [Pectobacterium polaris]
ATGTCCGTACAACCTATCCTTGCAAATGCAGCCGTGAGTATCAGCGACTTTAAAAAGTCCCCTAATGCCGCGCTTAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGCTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCAC
TGGCCGATTATCAGGAAGATATCGAACTCGCCAAAATTGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6