Detailed information of TA system TA066900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3920445..3921046
• Replicon: chromosome
• Accession: NZ_CP017482
• Organism: Pectobacterium polaris strain NIBIO1392

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: BJK05_RS17755
• Protein ID: WP_095701177.1
• Coordinates: 3920445..3920828 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A3S1A917
• Locus tag: BJK05_RS17760
• Protein ID: WP_010284263.1
• Coordinates: 3920825..3921046 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJK05_RS17715	3915675..3916175	+	501	WP_095701172.1	GrpB family protein	-
BJK05_RS17720	3916269..3917468	+	1200	WP_095701173.1	AI-2E family transporter	-
BJK05_RS17725	3917538..3917900	-	363	WP_095701991.1	DUF596 domain-containing protein	-
BJK05_RS17730	3917932..3918318	-	387	WP_192870331.1	hypothetical protein	-
BJK05_RS17735	3918445..3918990	+	546	WP_095701174.1	hypothetical protein	-
BJK05_RS17740	3919037..3919594	-	558	WP_095701175.1	hypothetical protein	-
BJK05_RS17745	3919629..3920066	-	438	WP_095701993.1	type II toxin-antitoxin system VapC family toxin	-
BJK05_RS17750	3920066..3920308	-	243	WP_095701176.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
BJK05_RS17755	3920445..3920828	-	384	WP_095701177.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
BJK05_RS17760	3920825..3921046	-	222	WP_010284263.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BJK05_RS17765	3921095..3921418	-	324	WP_095701178.1	hypothetical protein	-
BJK05_RS17770	3921694..3923631	-	1938	WP_095701179.1	ATP-binding protein	-
BJK05_RS17775	3923862..3924725	-	864	WP_095701180.1	YicC family protein	-
BJK05_RS17780	3924824..3925732	-	909	WP_095701181.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (2-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14285.17 Da
• Isoelectric Point: 6.8793

>T66900 WP_095701177.1 NZ_CP017482:c3920828-3920445 [Pectobacterium polaris]
MNWVSAQEVIAFHDRILQRLPGVAGMPDPGRAEAIIYRVQNRTHYEGITDVFELAATYWVAVARGHIFNDGNKRTAFFVT
MTFLYRNGVLVHDNDNTLENLTVEAATGAKNVDQLAQQLRTRVQLPG

Nucleotide

• Length: 384 bp

>T66900 NZ_CP017482:c3920828-3920445 [Pectobacterium polaris]
ATGAACTGGGTTAGCGCACAAGAGGTGATCGCCTTTCATGACCGGATCCTGCAACGTTTACCCGGCGTAGCGGGAATGCC
CGATCCGGGTCGAGCTGAAGCGATTATCTACCGGGTGCAGAATCGCACGCATTATGAAGGGATAACTGACGTCTTCGAGC
TGGCCGCCACTTACTGGGTGGCTGTTGCGCGTGGCCATATTTTTAATGATGGCAATAAGCGTACTGCGTTCTTCGTAACG
ATGACGTTTTTATACCGTAACGGCGTGCTGGTTCACGATAACGACAACACGTTGGAGAATCTGACGGTAGAGGCCGCTAC
GGGTGCAAAAAATGTTGACCAACTGGCACAGCAGTTGAGAACACGAGTGCAGCTTCCAGGCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8147.06 Da
• Isoelectric Point: 5.0359

>AT66900 WP_010284263.1 NZ_CP017482:c3921046-3920825 [Pectobacterium polaris]
MRIYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFEAYQNAKLDAEFDLIMQRHGHTIEALTDR

Nucleotide

• Length: 222 bp

>AT66900 NZ_CP017482:c3921046-3920825 [Pectobacterium polaris]
ATGCGAATCTACACCTCGACTCAAGCCAGAGCCAACATTTCAGAAGTATTAGACGCTGCAACCCACGGTGAACCGGTCGA
AATTACTCGTCGGGATGGAAGCTCTGCGGTGGTGATCAGCAAAGCGGAATTCGAGGCATACCAAAATGCCAAGTTAGACG
CCGAATTTGATCTCATCATGCAGCGCCACGGCCACACTATCGAAGCGCTGACTGACCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S1A917