Detailed information of TA system TA066892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 170785..171421
• Replicon: chromosome
• Accession: NZ_CP017482
• Organism: Pectobacterium polaris strain NIBIO1392

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7V8QAU7
• Locus tag: BJK05_RS00740
• Protein ID: WP_039485998.1
• Coordinates: 170785..170967 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BJK05_RS00745
• Protein ID: WP_095698792.1
• Coordinates: 170990..171421 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJK05_RS00710	166128..166331	+	204	WP_095701872.1	YbdD/YjiX family protein	-
BJK05_RS00715	166348..167334	+	987	WP_095698789.1	GTPase	-
BJK05_RS00720	167615..168997	+	1383	WP_095698790.1	right-handed parallel beta-helix repeat-containing protein	-
BJK05_RS00730	169231..169710	-	480	WP_014914564.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
BJK05_RS00735	169781..170599	-	819	WP_039485997.1	TraB/GumN family protein	-
BJK05_RS00740	170785..170967	+	183	WP_039485998.1	type II toxin-antitoxin system HicA family toxin	Toxin
BJK05_RS00745	170990..171421	+	432	WP_095698792.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BJK05_RS00750	171517..174240	-	2724	WP_095698793.1	copper-exporting P-type ATPase CopA	-
BJK05_RS00755	174358..174765	+	408	WP_039502918.1	Cu(I)-responsive transcriptional regulator	-
BJK05_RS00760	174803..175258	-	456	WP_095698794.1	NfeD family protein	-
BJK05_RS00765	175258..176172	-	915	WP_095698795.1	SPFH/Band 7/PHB domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-138)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6539.74 Da
• Isoelectric Point: 10.5014

>T66892 WP_039485998.1 NZ_CP017482:170785-170967 [Pectobacterium polaris]
MKSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Nucleotide

• Length: 183 bp

>T66892 NZ_CP017482:170785-170967 [Pectobacterium polaris]
ATGAAATCAACCGACCTGATAAAGGAGCTGGCAGCGGCAGGTTGTGAGTGCAAACGGCATAACGGCGGGAGTCACCAAAT
ATGGTGGTCACCCATTACTGGAAAAACGTTTCCAGTGCCGCATCCAAAAAAGGATTTACCACTTGGCACTGTCAAATCCA
TCAAAAAAATGGCGGGGATCTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 16054.99 Da
• Isoelectric Point: 4.3145

>AT66892 WP_095698792.1 NZ_CP017482:170990-171421 [Pectobacterium polaris]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTLIDEAVSRGNLDIKRLNDAGHLIYAAMPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Nucleotide

• Length: 432 bp

>AT66892 NZ_CP017482:170990-171421 [Pectobacterium polaris]
ATGTTTTTTTCAGTCGGTGTTGAAACGCCAAAAGATGATGCTACGGCATATGGGCTGATCGTTCCGGCATTGTGTACTGA
TGATTACGGCTGCTTCTCTGCGGCAGACAGCCAGCAAGAGATTGCACGCATGGCACGGGAAGCGATTTTAACCCTTATTG
ATGAAGCCGTGAGTCGTGGGAATCTGGATATTAAGCGACTTAATGACGCCGGACACCTTATCTATGCGGCGATGCCAGAT
TTTGCGGACTACGATAGTTGGTTCGTGCTGGATGTCGATCTATCGGCTTTTGAGGGAAAGCCGCAGCGATTGAACATTTC
TCTTCCCGATACATTGATACAGCGTATTGATAATCGCGTGCGAGAGCAGCCGGGTACTTATCGCGATCGCAGCCATTTTT
TGGCAGAAGCTGCACGCCATGAACTAGAGTAA

Structures

Toxin

• AlphaFold DB: A0A7V8QAU7