Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1382255..1382872 Replicon chromosome
Accession NZ_CP017481
Organism Pectobacterium polaris strain NIBIO1006

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BJJ97_RS06230 Protein ID WP_095700916.1
Coordinates 1382693..1382872 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BJJ97_RS06225 Protein ID WP_095700917.1
Coordinates 1382255..1382665 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ97_RS06210 1378128..1379171 - 1044 WP_095700919.1 DNA-binding transcriptional regulator CytR -
BJJ97_RS06215 1379466..1381664 - 2199 WP_095993397.1 primosomal protein N' -
BJJ97_RS06220 1381958..1382173 + 216 WP_010281510.1 50S ribosomal protein L31 -
BJJ97_RS06225 1382255..1382665 - 411 WP_095700917.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BJJ97_RS06230 1382693..1382872 - 180 WP_095700916.1 type II toxin-antitoxin system HicA family toxin Toxin
BJJ97_RS06235 1382971..1383981 - 1011 WP_095993398.1 iron ABC transporter permease -
BJJ97_RS06240 1383978..1384940 - 963 WP_095993399.1 ABC transporter substrate-binding protein -
BJJ97_RS06245 1384950..1385747 - 798 WP_095993400.1 ABC transporter ATP-binding protein -
BJJ97_RS06250 1385982..1386299 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
BJJ97_RS06255 1386487..1387647 + 1161 WP_039281157.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6550.65 Da        Isoelectric Point: 10.7838

>T66880 WP_095700916.1 NZ_CP017481:c1382872-1382693 [Pectobacterium polaris]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKSGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T66880 NZ_CP017481:c1382872-1382693 [Pectobacterium polaris]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAATTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCGAGCAAATCGGGACTAGTCACAATCCCCCACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCAGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14487.39 Da        Isoelectric Point: 4.3391

>AT66880 WP_095700917.1 NZ_CP017481:c1382665-1382255 [Pectobacterium polaris]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPAVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSAR

Download         Length: 411 bp

>AT66880 NZ_CP017481:c1382665-1382255 [Pectobacterium polaris]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACCCACGCATATGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCTATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCGCCGTGTCGTCAGTAGGCCAATTGGCAAAAAACGCAGAATACGCTGGGTACACATGGGCGGTT
GTTGATATCGACGTGACACGTTTAATGGGTGGTTCAGAAAAAATTAACGTCACACTGCCTAAGTCGCTGATTGACCGCAT
CGATCGTTGCGTAGCGAGTAATCCAGAATTTAAAAGTCGCTCAGGTTTTCTCGCACAGGCGGCATTAGAACGAATATCGT
CTGCTCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References