Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2757109..2757650 Replicon chromosome
Accession NZ_CP017478
Organism Urechidicola croceus strain LPB0138

Toxin (Protein)


Gene name parE Uniprot ID A0A1D8PA04
Locus tag LPB138_RS12275 Protein ID WP_070237567.1
Coordinates 2757109..2757411 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1D8P9Z3
Locus tag LPB138_RS12280 Protein ID WP_070237568.1
Coordinates 2757408..2757650 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB138_RS12245 2752613..2753107 - 495 WP_070237561.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
LPB138_RS12250 2753097..2753864 - 768 WP_070237562.1 TatD family hydrolase -
LPB138_RS12255 2753899..2754354 + 456 WP_070237563.1 retroviral-like aspartic protease family protein -
LPB138_RS12260 2754426..2754995 + 570 WP_070237564.1 RNA polymerase sigma factor -
LPB138_RS12265 2754976..2755761 + 786 WP_070237565.1 hypothetical protein -
LPB138_RS12270 2755790..2756851 + 1062 WP_070237566.1 hypothetical protein -
LPB138_RS12275 2757109..2757411 - 303 WP_070237567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPB138_RS12280 2757408..2757650 - 243 WP_070237568.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LPB138_RS12285 2757889..2759097 - 1209 WP_197505844.1 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase -
LPB138_RS12290 2759119..2761857 - 2739 WP_070237570.1 2-oxoglutarate dehydrogenase E1 component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12251.24 Da        Isoelectric Point: 10.2500

>T66872 WP_070237567.1 NZ_CP017478:c2757411-2757109 [Urechidicola croceus]
MSKNKYRISKQAINDLNDIWVYTFHKWSKEQADRYYDLIIGEIEFIADNYLIGKSAEQTRKNYRVTKIKSHLIFYRKVEN
EIVEIVRILHQRMDIKKRLK

Download         Length: 303 bp

>T66872 NZ_CP017478:c2757411-2757109 [Urechidicola croceus]
ATGAGTAAAAACAAATATCGAATAAGTAAACAAGCGATTAATGATTTAAATGATATTTGGGTATATACTTTTCACAAATG
GTCTAAAGAACAAGCCGACAGATATTATGACTTAATAATCGGAGAGATTGAGTTTATAGCGGACAACTATCTGATTGGAA
AATCCGCTGAACAAACTCGAAAAAACTATCGAGTAACGAAAATCAAATCGCATCTGATTTTTTACAGAAAAGTCGAAAAT
GAAATTGTTGAAATCGTTAGAATTTTACATCAGAGAATGGATATTAAAAAACGATTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9215.29 Da        Isoelectric Point: 5.6588

>AT66872 WP_070237568.1 NZ_CP017478:c2757650-2757408 [Urechidicola croceus]
MGKNTSISLGNHFEDFIREEVSSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVENFDPKQNLSELHRQHL

Download         Length: 243 bp

>AT66872 NZ_CP017478:c2757650-2757408 [Urechidicola croceus]
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGATTTTATCAGAGAGGAAGTAAGTTCTGGTAGATATGG
TTCTGTTAGCGAAGTAATTCGTTCAGCATTACGTTTGTTAGAACGTGAAGAAAAAAAGGAAAGAGAACTGATTAAAGCTC
TCGAAGTTGGAGAAAATAGTGGATTTGTTGAAAATTTTGACCCAAAACAAAACCTGTCTGAATTACATCGCCAACACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8PA04

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8P9Z3

References