Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 617051..617638 Replicon chromosome
Accession NZ_CP017477
Organism Polaribacter vadi strain LPB0003

Toxin (Protein)


Gene name PumA Uniprot ID A0A1B8U1T6
Locus tag LPB03_RS02785 Protein ID WP_065317986.1
Coordinates 617339..617638 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B8U1W1
Locus tag LPB03_RS02780 Protein ID WP_065317987.1
Coordinates 617051..617335 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB03_RS02770 613795..616236 + 2442 WP_065317988.1 M1 family metallopeptidase -
LPB03_RS02775 616253..617031 + 779 Protein_552 zinc-dependent peptidase -
LPB03_RS02780 617051..617335 - 285 WP_065317987.1 putative addiction module antidote protein Antitoxin
LPB03_RS02785 617339..617638 - 300 WP_065317986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPB03_RS16490 617729..617893 + 165 WP_083186959.1 zinc-dependent peptidase -
LPB03_RS02790 618150..618581 - 432 WP_065317985.1 hypothetical protein -
LPB03_RS02795 618758..619579 - 822 WP_083186956.1 cyclase family protein -
LPB03_RS02800 619753..621612 + 1860 WP_065317984.1 radical SAM protein -
LPB03_RS02805 621806..622318 - 513 WP_065317983.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11781.85 Da        Isoelectric Point: 10.4515

>T66870 WP_065317986.1 NZ_CP017477:c617638-617339 [Polaribacter vadi]
MFFIEKTIEFDKWLRKLKDFKAKAKIIFRIQKLEIDEHFGDSKSVGDGIRELRINYAKGYRIYFKEKDGKIIVLLIGGDK
STQQKDINKAKEIWNKLNK

Download         Length: 300 bp

>T66870 NZ_CP017477:c617638-617339 [Polaribacter vadi]
ATGTTCTTTATTGAGAAAACTATCGAATTTGACAAATGGCTAAGAAAATTGAAAGATTTTAAAGCCAAAGCAAAAATTAT
ATTTAGAATTCAGAAATTAGAGATTGATGAGCATTTTGGAGATTCTAAATCTGTAGGCGATGGAATAAGAGAGTTGAGAA
TTAATTATGCAAAAGGTTATCGAATTTATTTTAAAGAAAAAGATGGTAAAATAATTGTATTACTTATTGGTGGAGATAAA
TCTACCCAACAAAAAGACATCAACAAAGCAAAAGAAATCTGGAATAAATTAAATAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10147.66 Da        Isoelectric Point: 4.7361

>AT66870 WP_065317987.1 NZ_CP017477:c617335-617051 [Polaribacter vadi]
METSKFDIADYLDSKEMIAEYLNTVLEEGNTTDIINAIGHVAKAIGMTKISEETGLSRPSLYKALSDGSKPQFATIMKVL
KAIGGQIQINPISA

Download         Length: 285 bp

>AT66870 NZ_CP017477:c617335-617051 [Polaribacter vadi]
ATGGAAACTTCAAAATTTGATATAGCCGATTATTTAGACAGCAAGGAAATGATTGCTGAATATTTAAACACTGTTTTAGA
AGAAGGAAATACTACAGATATCATAAACGCAATTGGACATGTTGCAAAAGCAATAGGAATGACTAAAATATCTGAAGAAA
CTGGTTTAAGTAGACCTAGTTTATACAAAGCTTTATCTGATGGTTCTAAACCACAATTTGCAACAATAATGAAAGTTTTA
AAAGCAATTGGTGGCCAAATTCAAATAAATCCTATATCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8U1T6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8U1W1

References