Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3945358..3946018 Replicon chromosome
Accession NZ_CP017475
Organism Enterobacter cloacae strain M12X01451

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag GRI03_RS19505 Protein ID WP_023620447.1
Coordinates 3945358..3945771 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag GRI03_RS19510 Protein ID WP_013098615.1
Coordinates 3945752..3946018 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI03_RS19485 3941351..3943084 - 1734 WP_095908219.1 single-stranded-DNA-specific exonuclease RecJ -
GRI03_RS19490 3943090..3943803 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GRI03_RS19495 3943832..3944728 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
GRI03_RS19500 3944830..3945351 + 522 WP_013098613.1 flavodoxin FldB -
GRI03_RS19505 3945358..3945771 - 414 WP_023620447.1 protein YgfX Toxin
GRI03_RS19510 3945752..3946018 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
GRI03_RS19515 3946313..3947293 + 981 WP_095908220.1 tRNA-modifying protein YgfZ -
GRI03_RS19520 3947403..3948062 - 660 WP_003863433.1 hemolysin III family protein -
GRI03_RS19525 3948328..3949059 + 732 WP_058679193.1 MurR/RpiR family transcriptional regulator -
GRI03_RS19530 3949176..3950609 + 1434 WP_020687084.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T66866 WP_023620447.1 NZ_CP017475:c3945771-3945358 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T66866 NZ_CP017475:c3945771-3945358 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGCTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATCAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT66866 WP_013098615.1 NZ_CP017475:c3946018-3945752 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT66866 NZ_CP017475:c3946018-3945752 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References