Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3233033..3234816 Replicon chromosome
Accession NZ_CP017475
Organism Enterobacter cloacae strain M12X01451

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GRI03_RS16115 Protein ID WP_095908042.1
Coordinates 3233033..3234382 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GRI03_RS16120 Protein ID WP_029883072.1
Coordinates 3234379..3234816 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI03_RS16090 3228853..3229785 - 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -
GRI03_RS16095 3229953..3230351 + 399 WP_023619766.1 CidA/LrgA family protein -
GRI03_RS16100 3230348..3231043 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
GRI03_RS16105 3231173..3232057 + 885 WP_095908041.1 cytidine deaminase -
GRI03_RS16110 3232185..3232898 + 714 WP_023619764.1 outer membrane permeability protein SanA -
GRI03_RS16115 3233033..3234382 + 1350 WP_095908042.1 type II toxin-antitoxin system HipA family toxin Toxin
GRI03_RS16120 3234379..3234816 + 438 WP_029883072.1 helix-turn-helix domain-containing protein Antitoxin
GRI03_RS16125 3234868..3235878 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
GRI03_RS16130 3235894..3237414 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
GRI03_RS16135 3237495..3238493 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
GRI03_RS16140 3238788..3239810 - 1023 WP_020690130.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-403)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51227.82 Da        Isoelectric Point: 4.5722

>T66865 WP_095908042.1 NZ_CP017475:3233033-3234382 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVSDVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDSIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIMRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPIYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

>T66865 NZ_CP017475:3233033-3234382 [Enterobacter cloacae]
ATGGAGACGTTAACCGTACAAGCATATCTGAATGAAACATGGACGGATATCGCCCTCATCAAATATCCGGGAAGCGAAAA
AAATGACTGGAACACCACACAGTTAGACTATCTTACTGAGTATGCGATTAATTTTCTTGACTATGATGATTTTCACGCGG
TCTCAGTCAACCACCCTGTATCACTCTTTTTTGATGACCAAGGTCAACCGGGCTGGCTGCGATTTATCGACGATATCATT
CCTGCCGGAGCCAGTCGCCGTTATTGGATAAATGCACTCGATATCAGTGAGTTGCCTGTTGGTCAGCAGAATTTTTTATT
GTTGAAATTTGGCACAATGTCCCCTGTCGGGAATTTGCGTATAAAAGAATCCGTTCCTGAATGGAATGAATTCGCACGCA
CTAAAACGTTTACTGTTTCGGACGTCATCGATCGTGCGGCAGATTTTCTGGATTATGCCCAGGAAAGAGGCGCGGCGGCG
GGTGGCGCAACCGGCGCTGGGGGTGAAGCGCCGAAACTGTTGCTGCGCTGTAGTGAAACGGATTCCATCTGGATCGATAC
CTGGCAAAACGAGCCGGATAACCGGGACCGCTATTATTTGGTTAAATATCCACGCGGAAACAGAACAGAAGTTGATTGTA
ATATTCTCCGGGCTGAATTTCATTATTACCATGAGCTTAACGCGATGGGCTTTTCCACGATCCCAGTGGACACAATGCGC
CTTGAAGAAGGTAGCCACTATCCTTCTCTGTGGTTGCCACGTTTCGACATAATGAGAAATGAGCAGGATCAACTGATCAG
GCTGGGTATGGAATCGGTGTATTCACTATTACAAAAAGCACCCGGTACTCTCCTGGATCATGAGGCAACGCTGCGCGCGT
TAATTAATAAAATTACCTCCAGCCATATGGTTCAGCAGCAGGGCTATCAATTTGATATCCCTGGTTTTGTAACAGAATGG
GTACGTCGCGATCTGTTAAATATTATTTTTGGGAATAGTGACAACCATGGGCGAAATACCGCCTTTGTGAAAGCTGAAAA
TCACATTATGCTCTCCCCTATTTATGACTTTGCTCCAATGAAAGCCGATCCAGAGGGGATACCGCGAACCCTAAAGTGGT
CATTATCTTGTGAATCAGGGGGGGATTATAATTTCAACGCTATCGCGCAAGCGCTGGCGGAGTGGATCCCTCCCACAACT
TTACTTGACGCTCTGCATGATACAGCCGTCCAGCTCATCGATCTCCCGGAAAGGCTGGAGGCGCGAGGCGTTCCCGACCA
GATAATGGAAATGCCCGCGATTGGTTTTCGCTATATTCCGAATAAACTTTCTCGTTGGGGTTTATTATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT66865 WP_029883072.1 NZ_CP017475:3234379-3234816 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp

>AT66865 NZ_CP017475:3234379-3234816 [Enterobacter cloacae]
ATGAAAATATCTAATAAATCTGAATCAGAGCTTCTACAAACATTAGCCCGGGTACGCAGCGTAAATGAAAAGCGACGTCA
TGATGAGGATGAAGATCCGGACAAGTCATCGGTAGTAAAGAGGCAACGCGTTTCATCAGGCTTAACGCGGATTAGTACTC
TTGATCGCCAGGCTGTACTGCATGCAGCCATACGGGACATTTTACTGGGTAAAATCACACAGGGTGAGGCGCTGAAAAGA
CTCAGGGTCGAAGTGTTGGGGATGAAGCAGGATGAGTATGCAAAGCTGGTCAGCGTATCCCGGAAAACATTGTCGGATGT
AGAAAATGGCAGAGGTAATTATTCCGCTGACATTATAAATAAAATCTTTAAACCCTTTGGGCTTCAAACCGGACTGGTGC
CCATTTCCAAATCGCTTATAGCTTCACTTTTCACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References