Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2826199..2826898 Replicon chromosome
Accession NZ_CP017466
Organism Staphylococcus nepalensis strain JS11

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BJG89_RS13535 Protein ID WP_096811086.1
Coordinates 2826199..2826600 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BJG89_RS13540 Protein ID WP_096811087.1
Coordinates 2826656..2826898 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG89_RS13520 2821794..2822342 + 549 WP_096811084.1 YdhK family protein -
BJG89_RS14645 2822458..2822964 - 507 WP_198401685.1 hypothetical protein -
BJG89_RS14650 2823380..2824450 - 1071 WP_198401687.1 hypothetical protein -
BJG89_RS13530 2824991..2825446 + 456 WP_096811085.1 DUF805 domain-containing protein -
BJG89_RS13535 2826199..2826600 - 402 WP_096811086.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BJG89_RS13540 2826656..2826898 - 243 WP_096811087.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BJG89_RS13545 2827443..2828135 + 693 WP_096811088.1 ATP-binding cassette domain-containing protein -
BJG89_RS13550 2828138..2828911 + 774 WP_096811089.1 ABC transporter permease -
BJG89_RS13555 2829181..2829441 + 261 WP_096811090.1 hypothetical protein -
BJG89_RS13565 2829726..2829965 + 240 WP_096811092.1 DUF3923 family protein -
BJG89_RS13570 2830085..2830693 + 609 WP_096811093.1 stage II sporulation protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-87)

Antitoxin

SpoVT-AbrB domain

(10-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15412.82 Da        Isoelectric Point: 5.8914

>T66845 WP_096811086.1 NZ_CP017466:c2826600-2826199 [Staphylococcus nepalensis]
MQYLTEKDIITLNVYVINKYSPNEQIGVKEPNALNMLVNAPKQCVFGEEQYPTLELKAANLVRNLVQKHVFYNGNKRTAL
MTLVVFLKMNGYQFNASNEEVADYMVKIATDDLQEADIKQWIKKYITLMNEKD

Download         Length: 402 bp

>T66845 NZ_CP017466:c2826600-2826199 [Staphylococcus nepalensis]
ATGCAGTATTTAACAGAAAAAGACATTATCACACTAAATGTATATGTTATTAATAAATATAGCCCTAATGAGCAAATAGG
CGTAAAAGAACCAAATGCTTTAAATATGCTAGTTAACGCACCTAAGCAATGTGTATTTGGTGAAGAACAGTACCCCACTT
TAGAACTGAAAGCAGCTAACTTAGTTAGAAATTTAGTACAAAAACATGTGTTTTACAATGGTAATAAAAGAACAGCTTTA
ATGACATTGGTTGTTTTCCTTAAGATGAATGGATATCAGTTTAATGCTAGTAATGAAGAAGTGGCCGACTATATGGTTAA
AATTGCTACAGACGACTTACAGGAAGCAGACATTAAGCAATGGATTAAAAAGTATATAACACTAATGAATGAAAAGGATT
GA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8876.08 Da        Isoelectric Point: 4.5045

>AT66845 WP_096811087.1 NZ_CP017466:c2826898-2826656 [Staphylococcus nepalensis]
MAVTNTRKLRKIGNSKVLTIPEEVIQALDINEGQKIAFNVENGQVVLEAVKTDSNEMDILSMADQVSNQYDSALKDLVNR

Download         Length: 243 bp

>AT66845 NZ_CP017466:c2826898-2826656 [Staphylococcus nepalensis]
ATGGCAGTAACTAACACAAGAAAACTTAGAAAAATTGGCAATAGCAAGGTTCTAACAATACCAGAGGAAGTAATACAAGC
TTTAGATATTAATGAGGGACAAAAAATCGCATTTAACGTTGAGAATGGTCAAGTGGTATTAGAAGCAGTTAAAACGGATA
GTAACGAAATGGATATTTTAAGCATGGCCGATCAAGTAAGTAATCAGTATGATAGTGCTTTAAAAGATTTAGTGAATAGA
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References