Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1056607..1057136 Replicon chromosome
Accession NZ_CP017466
Organism Staphylococcus nepalensis strain JS11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BJG89_RS04840 Protein ID WP_096808815.1
Coordinates 1056774..1057136 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BJG89_RS04835 Protein ID WP_096808814.1
Coordinates 1056607..1056777 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG89_RS04810 1052390..1052869 + 480 WP_096808809.1 PH domain-containing protein -
BJG89_RS04815 1052862..1054367 + 1506 WP_096808810.1 PH domain-containing protein -
BJG89_RS04820 1054360..1054842 + 483 WP_096808811.1 PH domain-containing protein -
BJG89_RS04825 1054905..1055255 + 351 WP_096808812.1 holo-ACP synthase -
BJG89_RS04830 1055371..1056519 + 1149 WP_096808813.1 alanine racemase -
BJG89_RS04835 1056607..1056777 + 171 WP_096808814.1 antitoxin MazE Antitoxin
BJG89_RS04840 1056774..1057136 + 363 WP_096808815.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BJG89_RS04845 1057473..1058474 + 1002 WP_096808816.1 PP2C family protein-serine/threonine phosphatase -
BJG89_RS04850 1058543..1058869 + 327 WP_096808817.1 anti-sigma factor antagonist -
BJG89_RS04855 1058871..1059353 + 483 WP_096808818.1 anti-sigma B factor RsbW -
BJG89_RS04860 1059328..1060098 + 771 WP_096808819.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13581.66 Da        Isoelectric Point: 9.9426

>T66843 WP_096808815.1 NZ_CP017466:1056774-1057136 [Staphylococcus nepalensis]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDEKMQEVNNAIDISLGLHNIRNHRT

Download         Length: 363 bp

>T66843 NZ_CP017466:1056774-1057136 [Staphylococcus nepalensis]
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAATAAGACCCGTAGT
CATTATACAAAATGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCTGCAATTACTGGTAGGATTAATAAGGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGCAAGTATAAACTCGACAAAGACTCTGTTATTTTGTTAGAGCAAATACGT
ACTTTAGATAAAAACAGATTGAAAGAGAAATTAACATATTTATCTGATGAAAAAATGCAAGAGGTAAATAATGCTATAGA
TATTAGCTTAGGATTACATAATATTAGAAATCATAGAACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6355.98 Da        Isoelectric Point: 4.1920

>AT66843 WP_096808814.1 NZ_CP017466:1056607-1056777 [Staphylococcus nepalensis]
MASFNQNRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKHNNE

Download         Length: 171 bp

>AT66843 NZ_CP017466:1056607-1056777 [Staphylococcus nepalensis]
ATGGCAAGTTTTAATCAAAACAGAAATCATAGTATTGAACAACTTTTAAAAGAAGGCTATTCACAAATGGCTGACTTGAA
TCTCTCCCTTGCGGCGGAAGCATTTCCATTTGAATGTGAAGCTTGCGATTGCAATGAAGTCTACATTAGCTCTAAGCATA
ACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References