Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1044657..1045171 Replicon chromosome
Accession NZ_CP017466
Organism Staphylococcus nepalensis strain JS11

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag BJG89_RS04775 Protein ID WP_096808803.1
Coordinates 1044965..1045171 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag BJG89_RS04770 Protein ID WP_096808802.1
Coordinates 1044657..1044950 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG89_RS04750 1040327..1040965 + 639 WP_096808798.1 thiamine phosphate synthase -
BJG89_RS04755 1041053..1041922 + 870 WP_096808799.1 membrane protein insertase YidC -
BJG89_RS04760 1042058..1042711 - 654 WP_096808800.1 HD domain-containing protein -
BJG89_RS04765 1043031..1044515 - 1485 WP_096808801.1 cardiolipin synthase -
BJG89_RS04770 1044657..1044950 + 294 WP_096808802.1 copper-sensing transcriptional repressor CsoR Antitoxin
BJG89_RS04775 1044965..1045171 + 207 WP_096808803.1 heavy-metal-associated domain-containing protein Toxin
BJG89_RS04780 1045495..1045635 + 141 WP_002482742.1 hypothetical protein -
BJG89_RS04785 1045782..1046081 - 300 WP_096808804.1 transposase -
BJG89_RS04790 1046216..1047409 - 1194 WP_096808805.1 rod shape-determining protein RodA -
BJG89_RS04795 1047671..1048741 + 1071 WP_096808806.1 D-alanine--D-alanine ligase -
BJG89_RS04800 1048754..1050109 + 1356 WP_096808807.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7919.04 Da        Isoelectric Point: 4.6472

>T66842 WP_096808803.1 NZ_CP017466:1044965-1045171 [Staphylococcus nepalensis]
MNSQAIYIKNIENEANKIQIESHLAQLIGVYNVSVDKDYKRVLIDFKTPANLNNLEKEIYDLGFEILY

Download         Length: 207 bp

>T66842 NZ_CP017466:1044965-1045171 [Staphylococcus nepalensis]
ATGAATTCACAAGCGATTTATATAAAAAACATAGAAAATGAAGCAAACAAAATTCAAATTGAAAGTCATTTGGCGCAACT
TATAGGCGTATACAATGTTTCAGTTGATAAAGATTATAAGCGAGTGCTTATTGATTTTAAAACACCTGCAAATTTAAATA
ATTTAGAAAAAGAAATATATGATTTAGGTTTTGAAATTTTATACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11144.73 Da        Isoelectric Point: 6.8617

>AT66842 WP_096808802.1 NZ_CP017466:1044657-1044950 [Staphylococcus nepalensis]
MAETQKAHHSEQTKSNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp

>AT66842 NZ_CP017466:1044657-1044950 [Staphylococcus nepalensis]
ATGGCAGAAACGCAAAAAGCACACCATTCTGAACAAACTAAATCCAATTTAAAGTCTAGATTAAATCGTATCGAAGGCCA
AGTAAAAGCAATCAACCGCATGATAGATGAAGATGTATACTGTGATGATGTACTCACACAAATTAGAGCGACAAGATCTG
CTTTAAATAGCGTTGCAACAAAACTATTAGATCATCATATGAAGAGTTGTATCATGGACAAGGTCAATCAGGGCGAGCAG
CAAGAGGCTATGGATGAACTGTTAGTTACTTTTCAAAAATTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References