Detailed information of TA system TA066838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 967554..968357
• Replicon: chromosome
• Accession: NZ_CP017463
• Organism: Staphylococcus pasteuri strain JS7

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: BJG87_RS04815
• Protein ID: WP_017638030.1
• Coordinates: 968181..968357 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A654BAN2
• Locus tag: BJG87_RS04810
• Protein ID: WP_017638029.1
• Coordinates: 967554..968153 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJG87_RS04790	963453..964913	+	1461	WP_046466854.1	ABC transporter substrate-binding protein/permease	-
BJG87_RS04795	964906..965628	+	723	WP_046466853.1	amino acid ABC transporter ATP-binding protein	-
BJG87_RS04800	965771..966901	+	1131	WP_046466852.1	tRNA epoxyqueuosine(34) reductase QueG	-
BJG87_RS04805	966902..967372	+	471	WP_017638028.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
BJG87_RS04810	967554..968153	+	600	WP_017638029.1	glucosamine-6-phosphate isomerase	Antitoxin
BJG87_RS04815	968181..968357	+	177	WP_017638030.1	hypothetical protein	Toxin
BJG87_RS04820	968509..968901	+	393	WP_017638031.1	hypothetical protein	-
BJG87_RS04825	969057..970442	+	1386	WP_046466851.1	class II fumarate hydratase	-
BJG87_RS04830	970502..971332	-	831	WP_029056289.1	RluA family pseudouridine synthase	-
BJG87_RS04835	971512..972624	+	1113	WP_029056288.1	GAF domain-containing sensor histidine kinase	-
BJG87_RS04840	972645..973268	+	624	WP_029056287.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6787.12 Da
• Isoelectric Point: 3.8537

>T66838 WP_017638030.1 NZ_CP017463:968181-968357 [Staphylococcus pasteuri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSDVRSDLEE

Nucleotide

• Length: 177 bp

>T66838 NZ_CP017463:968181-968357 [Staphylococcus pasteuri]
ATGACACAAAATAAAGATTCTAAAACTAATTATCATGAAGAAGAAAATGCTATGGTAACTGATTTAGATGATTTAAAAGA
TTTAGGTAAAGAAATGGAACAAATTTCTGAGGAAAATGATGAAGATAAATTAAACCAATCACATGATTCAGATGTTCGTT
CTGATTTAGAAGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22646.58 Da
• Isoelectric Point: 4.9933

>AT66838 WP_017638029.1 NZ_CP017463:967554-968153 [Staphylococcus pasteuri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVELHAVDFSQINILDYDENKSYYEALGV
PQSQIYSLSYNQDANEFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT66838 NZ_CP017463:967554-968153 [Staphylococcus pasteuri]
ATGGCAATGAACTTTAAAGTATTCGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAGTTTAA
CAACAATCCTATGACTATCGCTGGTGTTCACTTAACTAAAGACCATGCACCTGTATTAGATGAACTTAAAAAGAACGTTG
AGTTACATGCAGTTGATTTTAGTCAAATTAACATTTTAGATTATGATGAAAATAAATCATACTATGAAGCTTTAGGCGTA
CCTCAAAGCCAAATTTATTCATTATCTTATAATCAAGATGCTAATGAATTTATTTCTGATAAAATTAAAACAAAAGAAAA
TAAAGGTAAATTAGTGTTACAAGTAGTTTCTATTGATGAGAATGGCAACCTTGATGTAAGCGTAAGACAAGGATTATTAG
AAGCGCGTGAAATTTTCTTAGTTGTTACTGGTAGCAATAAACGCGAAGTAGTTGAAAAATTATATAATGAAAATGGTAAG
TCTAATTATGAACCAGCAGATTTAAAAGCTCATCGCATGGTTAACGTTATTTTAGATAAAGAAGCAGCGGCTGGATTACC
TGAAGATGTTAAAGAATACTTCACTGCTCGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A654BAN2