Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 813780..814309 Replicon chromosome
Accession NZ_CP017463
Organism Staphylococcus pasteuri strain JS7

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2NNE2
Locus tag BJG87_RS03920 Protein ID WP_029056198.1
Coordinates 813947..814309 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag BJG87_RS03915 Protein ID WP_002451626.1
Coordinates 813780..813950 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG87_RS03890 809597..810070 + 474 WP_029056193.1 PH domain-containing protein -
BJG87_RS03895 810063..811595 + 1533 WP_046466912.1 PH domain-containing protein -
BJG87_RS03900 811582..812076 + 495 WP_046466913.1 PH domain-containing protein -
BJG87_RS03905 812114..812491 + 378 WP_046466914.1 holo-ACP synthase -
BJG87_RS03910 812540..813688 + 1149 WP_046466915.1 alanine racemase -
BJG87_RS03915 813780..813950 + 171 WP_002451626.1 hypothetical protein Antitoxin
BJG87_RS03920 813947..814309 + 363 WP_029056198.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BJG87_RS03925 814631..815632 + 1002 WP_017637330.1 PP2C family protein-serine/threonine phosphatase -
BJG87_RS03930 815727..816053 + 327 WP_029056199.1 anti-sigma factor antagonist -
BJG87_RS03935 816055..816534 + 480 WP_017637328.1 anti-sigma B factor RsbW -
BJG87_RS03940 816509..817279 + 771 WP_029056200.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13572.72 Da        Isoelectric Point: 9.9783

>T66837 WP_029056198.1 NZ_CP017463:813947-814309 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T66837 NZ_CP017463:813947-814309 [Staphylococcus pasteuri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGT
TATTATTCAAAATGACACAGGTAATAAATATAGTCCAACAGTAATTGTTGCAGCAATTACTGGAAGGATTAACAAAGCTA
AGATACCCACACATGTAGAAATAGAAAAGAAGAAGTATAAACTTGATAAAGATTCTGTAATCTTACTTGAACAAATTCGA
ACGTTAGATAAAAATCGTTTGAAAGAAAAGCTCACATATTTGTCAGATAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGATTACATAATTTTAATCATCCAAAGACTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT66837 WP_002451626.1 NZ_CP017463:813780-813950 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT66837 NZ_CP017463:813780-813950 [Staphylococcus pasteuri]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCAATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2NNE2

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References