Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 802632..803142 Replicon chromosome
Accession NZ_CP017463
Organism Staphylococcus pasteuri strain JS7

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0M2NRR1
Locus tag BJG87_RS03860 Protein ID WP_046466909.1
Coordinates 802936..803142 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A654BGA3
Locus tag BJG87_RS03855 Protein ID WP_017636753.1
Coordinates 802632..802925 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG87_RS03830 797785..798576 + 792 WP_046466905.1 hydroxyethylthiazole kinase -
BJG87_RS03835 798577..799218 + 642 WP_046466906.1 thiamine phosphate synthase -
BJG87_RS03840 799307..800176 + 870 WP_017636756.1 membrane protein insertase YidC -
BJG87_RS03845 800215..800859 - 645 WP_046466907.1 HD domain-containing protein -
BJG87_RS03850 800959..802443 - 1485 WP_046466908.1 cardiolipin synthase -
BJG87_RS03855 802632..802925 + 294 WP_017636753.1 copper-sensing transcriptional repressor CsoR Antitoxin
BJG87_RS03860 802936..803142 + 207 WP_046466909.1 heavy-metal-associated domain-containing protein Toxin
BJG87_RS03865 803280..803417 + 138 WP_017636751.1 hypothetical protein -
BJG87_RS03870 803552..804742 - 1191 WP_046466910.1 rod shape-determining protein RodA -
BJG87_RS03875 805114..806184 + 1071 WP_096807747.1 D-alanine--D-alanine ligase -
BJG87_RS03880 806200..807561 + 1362 WP_017636748.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(17-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7657.60 Da        Isoelectric Point: 4.1598

>T66836 WP_046466909.1 NZ_CP017463:802936-803142 [Staphylococcus pasteuri]
VQQKIVYTSGIETTEQANKMETILKEMIGVYDANVDLSNGHISVEFETPANLNSIEKEIYDSGFKVLY

Download         Length: 207 bp

>T66836 NZ_CP017463:802936-803142 [Staphylococcus pasteuri]
GTGCAACAAAAAATTGTTTATACTTCAGGAATCGAAACGACTGAACAAGCTAACAAAATGGAAACAATATTAAAGGAAAT
GATAGGTGTATATGATGCAAATGTAGATCTTAGCAATGGTCACATTTCAGTTGAATTTGAGACACCTGCTAATTTAAATA
GTATAGAAAAAGAAATTTATGATTCTGGATTTAAAGTGCTTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.74 Da        Isoelectric Point: 6.3270

>AT66836 WP_017636753.1 NZ_CP017463:802632-802925 [Staphylococcus pasteuri]
VTEQDHAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCITEKVNNGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT66836 NZ_CP017463:802632-802925 [Staphylococcus pasteuri]
GTGACAGAACAAGATCATGCACATCACTCAGAACAAATTAAAACAAATTTGAAATCAAGATTAAATAGAATTGAAGGACA
AGTTCGTGCTATCAACCGAATGATAGAAGAAGATGTTTATTGTGATGATGTTTTAACACAAATTAGAGCAACACGTTCAG
CTTTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATAACTGAAAAAGTCAATAATGGTCATCAA
GAAGAAGCCATGGAAGAGTTACTTGTAACTTTTCAAAAATTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2NRR1

Antitoxin

Source ID Structure
AlphaFold DB A0A654BGA3

References